1.      Name : Srikrishna Saripella

2.      Designation: Professor

3.       Contact Information: Office

 

Department of Biochemistry
Faculty of Science
Banaras Hindu University,

Vranasi-221005, U.P., INDIA
Phone: +91-542-6702460

Fax: +91-0542-2368174 (Univ)

Email Id: [email protected]; [email protected]; [email protected]

Home: Old L-18, Hyderabad colony, Banaras Hindu University, Varanasi- 221 005

 

4.      Academic Qualification:

S. No

Degree

Institution

Year

1.

B.Sc. (Hons)

Andhra University

1993

2.

M.Sc.

Andhra University

1996

3.

Ph.D.

Banaras Hindu University

2008

 

5.      Area of Specification: Molecular Neurogenetics & Cancer Cell Biology

Our current research interests: 

Our lab is principally working towards understanding of the Genetic, Molecular and Biochemical basis of Human neurodegenerative diseases and Cancer using Drosophila transgenic model system. The quest to find cure for human diseases involves understanding the molecular and cellular mechanisms of the disease process and finding drugs that alleviate the disease/disease symptoms. Our ultimate aim is to devise potential drug targets and therapeutics for these devastating diseases. In this context our lab is working on the following areas:

1. Parkinson�s disease model of Drosophila

Protein quality control machinery is indispensable for preserving protein structural and functional integrity, essential for almost every aspect of routine cellular activity. One of such comprises an ubiquitin mediated quality control involving RBR ligases, a class of E3 ubiquitin ligases. Parkin, an RBR ligase has gained a lot of attention as its loss of function mutation is associated with familial forms of autosomal�recessive juvenile Parkinsonism (AR-JP). Parkin is crucial for alleviating unfolded protein stress, mitochondrial remodeling, mitophagy, transcriptional regulation, JNK regulation, systemic fat metabolism, and also has a role in fertility. We are currently working on the parkin loss associated discrepancies in Drosophila model using tissue specific RNAi and in parkin null backgrounds. Our major focus is parkin loss associated events in mitochondrial energetics, metal homeostasis and p53 mediated mitochondrial dependent apoptotic cascade. Further, we are also utilising the different therapeutic approaches in fly model to compensate for the parkin loss and to decipher the underlying mechanics involved.

2. Alzheimer�s disease Model of Drosophila

Alzheimer's disease (AD) is the most common human neurodegenerative disorder leading to dementia. It accounts for two-thirds of all cases of dementia and its prevalence increases with age. AD affects millions of people worldwide, represent a huge and increasing burden on the health-care system, and constitute one of the major challenges of modern medicine. Unfortunately, the cause and pathogenic mechanisms underlying this devastating disorder is poorly understood and, therefore, no effective treatment available till date. Our laboratory is working towards suitable protective and therapeutic approaches for the treatment of AD using variety of synthetic as well as natural compounds like metal chelator based therapeutic approaches, neuroprotective potential of flavonoids and natural polyphenols, etc.

3. Cancer disease model of Drosophila

Cancer is one of the main causes of high rate of human mortality worldwide and anticipated deaths from cancer across the globe will rise over 11 million by 2030. Currently, our lab is working towards the development of somatic and germ-line cancer model in Drosophila to study tumor microenvironment and screening of large scale anti-cancer compounds/drugs. The in vivo fly cancer model is developed, through combination of gain of function mutation in oncogenes and loss of function mutation in the tumor suppressor genes, to induce metastasis. Oncogene- Ras and tumor suppressor genes like scrib, l(2)gl and dlg are well known for their involvement in cancer development in the fly model system, but the underlining mechanisms by which these candidates are regulating cell growth and apoptosis in tumor cells are not quite clear. Our studies on in vivo fly model and in vitro human cancer cell lines in the context of these candidates would help deciphering novel therapeutic targets towards the development of anticancer drugs for this devastating disease.

 

 

 

 

 

6.      Project Undertaken as PI/ Co PI (if any) :

 

S. No.

Name of the Project

Duration

Source

Amount (in Rs)

1

Identification of novel genetic/ molecular candidates responsible for Metastatic Cancers using RNAi approach and in vitro/in vivo screening of some synthetic compounds having anticancer activity in Drosophila. (PI)

2015-2019

Science and Engineering Research Board (SERB), New Delhi

45,84,000.00

1

Genetic and molecular studies on Parkin interactors associated with mitochondrial dysfunction in Parkinson�s disease

2013-2016

Department of Biotechnology (DBT),

New Delhi

40,00,000.00

2

Effect of withanolide on chronic circadian rhythm disruption -induced cognitive deficit in mice

2013-2016

Department of Science and Technology (DST-CSI), New Delhi

35,00,000.00

3

Identification and characterization of novel genetic/ molecular candidates of Cancer progression and Metastasis using Genomic and Proteomic approaches in fly model system

2012-2013

UGC-UPE

Banaras Hindu University

2,00,000.00

4

Identification of Leishmanial antigens modulating NRAMP1 efflux pump function

2009-2012

Department of Biotechnology (DBT),

New Delhi

50,00,000.00

 

  1. List of 10 major Publications:

1.       AK Yadav, S Srikrishna*, SC Gupta. (2016) Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back. Trends in Pharmacological Sciences, 37 (9), 789-806. (Cover page article) (IF: 12).

 

2.       Navin Kumar, Arvind Kumar Dubey, Atul Kumar Upadhyay, Ambedkar Gautam, Ruma Ranjan, Saripella Srikishna, Nayan Sahu, Soumit Kumar Behera, Shekhar Mallick (2017). GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic. Scientific Reports (Nature), 7: 8786 | DOI:10.1038/s41598-017-09428-2. (IF: 4.8).

 

3.       Sandeep Kumar Singh1, Saurabh Srivastav1, Amarish Kumar Yadav1 and Saripella Srikrishna1* (2017) Knockdown of APPL mimics transgenic Aβ induced neurodegenerative phenotypes in Drosophila. Neuroscience Letters, 648, 8-13. (IF: 2.2).

 

4.       Prashant Swapnil, Amarish Kumar Yadav, Saurabh Srivastav, Naveen K Sharma, Saripella Srikrishna, Ashwani K Rai (2017) Biphasic ROS accumulation and programmed cell death in a cyanobacterium exposed to salinity (NaCl and Na 2 SO 4). Algal Research, 23, 88-95. (IF: 5.1).

 

5.       SK Singh, S Srivastav, AK Yadav, S Srikrishna*, G Perry (2016) Overview of Alzheimer�s Disease and Some Therapeutic Approaches Targeting A by Using Several Synthetic and Herbal Compounds. Oxidative Medicine and Cellular Longevity, Volume 2016, Article ID 7361613, 22 pageshttp://dx.doi.org/10.1155/2016/7361613. (IF: 4.6).

 

6.       P Srivastava, SS Razi, R Ali, S Srivastav, S Patnaik, S. Srikrishna, A Misra (2016) Highly sensitive cell imaging �Off�On� fluorescent probe for mitochondria and ATP.. Biosensors and Bioelectronics 69, 179-185. (IF: 7.5).

 

7.       Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, and Saripella Srikrishna*. (2015) Folic acid supplementations alleviate anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinsons disease. Biochemical and Biophysical Research Communications, 460(3): 780-5. (IF: 2.5).

 

8.       Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, and Saripella Srikrishna*. (2015) Folic Acid supplementation ameliorates oxidative stress, metabolic functions and developmental anomalies in a novel fly model of Parkinson�s disease. Neurochemical Research,. DOI 10.1007/s11064-015-1598-x. (IF: 2.6).

 

9.       Sandeep Kumar Singh, Ruchi Gaur, Akhil Kumar, Roshan Fatima, Lallan Mishra and Saripella Srikrishna (2013) Neuroprotective activity of 2-(4′-benzyloxyphenyl)-3-hydroxy-chromen-4-one against Aβ42 induced Neurodegeneration by in silico and in vivo studies in Alzheimer�s model of Drosophila. Neurotoxicity Research, 26 (4), 331-350. (IF: 3.5).

10.   Flora L. Thorp-Greenwood, Michael P. Coogan, Lallan Mishra, Niraj Kumari, Geeta Rai and Srikrishna Saripella (2012) The Importance of Cellular Localisation of Probes: Synthesis, Photophysical Properties, DNA Interactions And Cellular Imaging Properties Of Rhenium Dppz Complexes With Known Cellular Localisation Vectors. New Journal of Chemistry, 36, 64-72. (Cover page article) (IF: 3.16)

8.       Awards / Recognition :

�         Junior Research Fellow (JRF), CSIR (Council of Scientific and Industrial Research, New Delhi), December 1997

�         Lectureship, SLET (State Level Eligibility Test), APCSC (Andhra Pradesh College Service Commission, Hyderabad), February 1997

�         Lectureship, SLET (State Level Eligibility Test), APCSC (Andhra Pradesh College Service Commission, Hyderabad), July 1997

 

 

 

 

9.      Additional Information / Achievements :

Presented in Conferences/ Symposia/ Workshops etc.:

S.N

Title of Paper/Art Presented

Title of Conference

Organizer(s)

1

scribble knockdown induces tumorigenesis by

modulating Drp1-Parkin mediated mitochondrial dynamics in Drosophila wing imaginal disc

Amarish Kumar Yadav and S. Srikrishna*

3rd biennial Indian Drosophila Research Conference. 6th -9th December, 2017

Indian Institute of Science Education and Research (IISER), Bhopal

2

scrib abrogation in wing imaginal discs leads to

tumor growth and metastasis. Amarish Kumar

Yadav and S. Srikrishna*

Gene-environment interaction in Development, Disease and Evolution,

5th � 6th March, 2017

Cytogenetics, Department of Zoology, BHU, Varanasi

3

Abrogation of scrib leads to Cancer

progression through JNK mediated Wnt

signaling in Drosophila.

Amarish Kumar Yadav and S. Srikrishna*

26th National congress of Parasitology

21st-23rd January, 2016

Department of Biochemistry, Institute of Science, BHU, Varanasi

4

Orally administered 5-bromo-3-hydroxy-3-

(2-oxo-2-phenylethyl)-indol-2-one alleviates

early pupal lethalityin scribble knockdown

Drosophila cancer model. Amarish Kumar Yadav,

Saurabh Srivastav, Sandeep Kumar Singh,

Alpana K. Gupta and S. Srikrishna*

XXXVIII All India Cell Biology Conference and International Symposium on �Cellular Response to Drugs� December 10-12, 2014

CSIR-CDRI (Central Drug Research Institute), Lucknow

5

Modeling Human Diseases in Drosophila for

potential therapeutics. Saripella Srikrishna*

Drosophila meeting

March 12-13, 2014

Department of Zoology, BHU

6

Neuroprotective and anti cancer activity of

various synthetic compounds in transgenic

model of Drosophila. Saripella Srikrishna*

Genomic and Proteomic Analysis of Cellular Functions

September 14, 2013

UGC UPE, BHU

7

Parkin co-operates with F-actin in maintenance and movement of investment cones during spermatogenesis in Drosophila. Saurabh Srivastav and Saripella Srikrishna*

5th Bangalore Microscopy Course, NCBS-TIFR, Bangalore, Septemebr 8-15, 2013.

NCBS (National Centre for Biological Sciences, TIFR, Bangalore.

8

Neuroprotective role of a novel Copper chelator against Aβ42 induced Neurotoxicity in Drosophila model of Alzheimer�s disease

Sandeep Singh and Saripella Srikrishna*

 

XXX Annual Meeting of Indian Academy of Neurosciences. Traslational Neurosciences Unraveling Misteries of Brain and Health Diseases. October 27th - 30th, 2012
Department of Biotechnology,
Guru Nanak Dev University,
Amritsar-143005, India.

9

parkin gene mutation results in elevated oxidative stress with developmental disparity accompanied with sexual dysfunction in Drosophila melanogaster

Saurabh Srivastav and Saripella Srikrishna*

 

XXXVI All India Cell Biology Conference & International Symposium on �Stress Adaptive Response and Genome Integrity (SARGI)� October, 2012

Bhabha Atomic Research Centre (BARC) Mumbai,

10

Filarial Hsp90: A potential drug target.

Abhinav Joshi, Saurabh Srivastava, Saripella Srikrishna and Sushma Rathaur

 

6th International Conference on the Hsp90 Chaperone Machine.

September 19-23, 2012

Didier Picard & Johannes Buchner,

Les Diablerets, Switzerland

11

Orally administered 2-(4-benzyloxyphenyl)-3-hydroxy-chromen-4-one rescues the eye phenotypes in a transgenic Drosophila model of Alzheimer�s disease.

Sandeep Singh and Saripella Srikrishna*

International Conference

on Advances In Biological

Sciences (ICABS-2012)

15-17 March 2012

Biotechnology

and Microbiology
Kannur University, Kerala

12

Increased ROS activity due to Benzyl viologen dichloride (Paraquat) treatment and parkin knockdown result in developmental delay reduced life span, flight disability and absolute sterility in Drosophila.

Saurabh S and Saripella Sriskrishna*

Reactive Oxygen Species:

Roles in Animal and Plant

Biology, 23rd   to  24th

December 2011 

Department of Biochemistry, Lucknow University, Lucknow

13

Mitochondrial dynamics: Impaired balance of Mitochondrial fusion, fission and mitophagy in Parkinson�s neurodegenerative disease.

Saripella Srikrishna*

Brain Storming Meeting on Translational Neuroscience,

during 17/18 September,

2011

Brain Research

Centre, BHU,

Varanasi-India

14

Identification of urinary leishmanial antigens

for their diagnostic and prognostic potentials.

Jalaj Gaur, Vinod Kumar, S. Srikrishna & R.K. Singh

International Conference on

the Role of Biomolecules in

Food Security and Health

Improvement (ICBFH-2010)

Banaras Hindu

University,

Varanasi

15

The Non-coding hsrw RNA is required for oocyte development and fertility in Drosophila

melanogaster .

Saripella Srikrishna and S. C. Lakhotia*

XXVII All India Cell Biology

Conference & International

Symposium-2004

University of Pune, Pune-411007, India

16

Studies on proteins interacting with the non-

coding hsrw mutants during oogenesis in

Drosophila melanogaster.

Saripella Srikrishna and S. C. Lakhotia*

XXVI All India

Cell Biology

Conference-2002

ACTREC,

Navi Mumbai,

India.

 

 

 

 

  1. Participated in Seminars/Symposia/Conferences/Workshops etc.:
  1. Eleventh Teacher/Researcher Training Workshop on �Teaching and Learning Genetics with Drosophila. December 29, 2014 � January 10, 2015, Indian Institute of Science, Bangalore-560 012.
  2. Advanced Course on Genes and Behavior Workshop, October 29 � November 9, 2012, National Centre for Biological Sciences (NCBS), TIFR, Bangalore � 560 065.
  3. Symposium on Population Genetics and Chromatin Dynamics, January 22-23, 2012, Banaras Hindu University, Varanasi-221 005.
  4. International Conference on �Functional Genomics: Challenges and Prospects�, 02-04 October 2010, Banaras Hindu University, Varanasi-221 005.
  5. International Conference on �Role of Biomolecules in Food security & Health improvement (ICBFH)�, 17-20 February 2010, Banaras Hindu University, Varanasi-221 005.
  6. International Conference on Emerging Trends in Biotechnology (ETBT), 4-6 December 2009, Banaras Hindu University, Varanasi-221 005.
  7. Seminar and Training on Spectral Confocal LASER Scanning Microscopy, October 13-15, 2009, University of Delhi, South Campus, New Delhi-110 021.
  8. XXXI All India Cell Biology Conference & Symposium on �Stem Cells: Applications and Prospects� from December 14-16, 2007, Banaras Hindu University, Varanasi- 221 005.
  9. European Molecular Biology Organization (EMBO) Workshop, 16-20 December 2006, Department of Biological Sciences and Bioengineering, Indian Institute of Technology (IIT), Kanpur.
  10. International symposium on Environmental Factors, Cellular Stress and Evolution, 13-15 October 2006, Banaras Hindu University, Varanasi-221 005.
  11. XXVII All India Cell Biology Confernce & International Symposium, Jan 7-10, 2004, University of Pune, Pune-411007, India.
  12. XXVI All India Cell Biology Conference, 12-14 DECEMBER, 2002 ACTREC, Navi Mumbai, India.
  13. National Laboratory Workshop on Multiphoton Confocal Microscopy held at the DST national Facility for Multiphoton Confocal Microscopy, Cytogenetics Laboratory, October 21-26, 2002, Banaras Hindu University, Varanasi-221 005.
  14. XXIII All India Cell Biology Conference, November 27-29, 1999, Center for Cellular and Molecular Biology (CCMB), Hyderabad.

 

 

11. Other achievements:

  1. Member, Board of studies of Biochemistry department, Aligarh Muslim University, 2017-2019.
  2. Member, Institution of Eminence Committee, Banaras Hindu University, October 2017.
  3. Member, Compassionate Appointments Committee, Banaras Hindu University since January 2017.
  4. Member of Design and Innovation Centre (DIC), IIT-BHU,
  5. Member of FAC committees, BHU, etc.
  6. Member, UG & PG Admission committee of the Institute
  7. Deputy Professor In charge, Seminar Complex, Institute of Science, BHU.
  8. Member, Selection committees for faculty recruitments at University level
  9. Member, nonteaching recruitments, school board recruitments and other routine selection committees at University and Institute levels
  10. Co-Organizing Secretary, 26th National Indian Parasitology Conference, February, 2016
  11. Member, University of Excellence Committee (BHU), 2016
  12. Member, UACB (University Admission Coordination Board), 2015 & 2017
  13. Member, Admission Committee, Instute of Science, BHU, 2015
  14. Member, Registration Committee, BHU Alumni Meet 2015
  15. Member, Mess Maintenance and Monitoring Committee, Banaras Hindu University, 2012
  16. Member, Organizing committee, International Conference on �Functional Genomics: Challenges and Prospects�, BHU, 2010
  17. Treasurer, International Conference on role of Biomolecules in Food security & Health improvement (ICBFH), BHU, 2010
  18. Member, Organizing committee, International Conference on Emerging Trends in Biotechnology (ETBT), BHU, 2009
  19. Member, Teachers Grievance committee, Banaras Hindu University, 2010-12
  20. Member, Selection Committee for JRF and SRF recruitments in Faculty of Science, Institute of Technology and Institute of Medical Sciences, BHU.
  21. Member, Registration Committee, BHU Alumni Meet 2010 and Seminar on Higher Education and Sustainable Development: Emerging Challenges and Mahamana's Vision, BHU, Varanasi-221-005.

 

  1. Membership in Scientific Societies:

Life member, Indian Academy of Neuroscience, New Delhi since 2015

Life Member, Alzheimer�s & Related Disorders Society of India (ARDSI) since 2011

Member, Indian Society of Cell Biology since 1998

Member, Society of Biological Chemists, India (1994-1996)

  1. Full list of Publications:

1.      AK Yadav and S Srikrishna* (2017). scribble (scrib) knockdown induced tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila (In Press, Mitochondrion).

 

2.      Romi Dwivedi, Divya Pratap Singh, Brijesh Singh Chauhan, S Srikrishna, Anoop Kumar Panday, Lokman H Choudhury, Vinod Prasad Singh (2017). Intracellular application and logic gate behavior of a �turn off-on-off�type probe for selective detection of Al 3+ and F− ions in pure aqueous medium. Sensors and Actuators B: Chemical, 2017.

3.      Navin Kumar, Arvind Kumar Dubey, Atul Kumar Upadhyay, Ambedkar Gautam, Ruma Ranjan, Saripella Srikishna, Nayan Sahu, Soumit Kumar Behera, Shekhar Mallick (2017). GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic. Scientific Reports (Nature), 7: 8786 | DOI:10.1038/s41598-017-09428-2.

 

4.      Sandeep Kumar Singh1, Saurabh Srivastav1, Amarish Kumar Yadav1 and Saripella Srikrishna1* (2017) Knockdown of APPL mimics transgenic Aβ induced neurodegenerative phenotypes in Drosophila. Neuroscience Letters, 648, 8-13.

 

5.      Prashant Swapnil, Amarish Kumar Yadav, Saurabh Srivastav, Naveen K Sharma, Saripella Srikrishna, Ashwani K Rai (2017) Biphasic ROS accumulation and programmed cell death in a cyanobacterium exposed to salinity (NaCl and Na 2 SO 4). Algal Research, 23, 88-95.

 

6.      Kamini Tripathi, Abhishek Rai, Amarish Kumar Yadav, Saripella Srikrishna, Niraj Kumari and Lallan Mishra (2017) Fluorescein hydrazone-based supramolecular architectures, molecular recognition, sequential logic operation and cell imaging. RSC Advances, 7 (4), 2264-2272.

 

7.      Abhishek Rai, Niraj Kumari, Ashish Kumar Srivastava, Sandeep Kumar Singh, Saripella Srikrishna, Lallan Mishra (2016) Rhodamine hydrazone as OFF�ON�OFF type selective sequential sensor of Al 3+ and N 3− ions. Journal of Photochemistry and Photobiology A: Chemistry, 319, 78-86.

8.      AK Yadav, S Srikrishna*, SC Gupta. (2016) Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back. Trends in Pharmacological Sciences, 37 (9), 789-806

 

9.      SK Singh, S Srivastav, AK Yadav, S Srikrishna*, G Perry (2016) Overview of Alzheimer�s Disease and Some Therapeutic Approaches Targeting A by Using Several Synthetic and Herbal Compounds. Oxidative Medicine and Cellular Longevity, Volume 2016, Article ID 7361613, 22 pageshttp://dx.doi.org/10.1155/2016/7361613.

 

10.  P Srivastava, SS Razi, R Ali, S Srivastav, S Patnaik, S. Srikrishna, A Misra (2016) Highly sensitive cell imaging �Off�On� fluorescent probe for mitochondria and ATP.. Biosensors and Bioelectronics 69, 179-185.

 

11.  Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, and Saripella Srikrishna*. (2015) Folic acid supplementations alleviate anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinsons disease. Biochemical and Biophysical Research Communications, 460(3): 780-5.

 

12.  Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, and Saripella Srikrishna*. (2015) Folic Acid supplementation ameliorates oxidative stress, metabolic functions and developmental anomalies in a novel fly model of Parkinson�s disease. Neurochemical Research,. DOI 10.1007/s11064-015-1598-x.

 

13.  Akhil Kumar, Swati Srivastava, Shubhandra Tripathi, Sandeep Kumar Singh, Saripella Srikrishna, Ashok Sharma. (2015). Molecular insight into amyloid fibril destabilizing mechanism of Flavonoid Derivative 2-(4′ Benzyloxyphenyl)-3-hydroxy-chromen-4-one through docking and molecular dynamics simulations. Journal of Bimolecular Structure & Dynamics,. DOI: 10.1080/07391102.2015.1074943.

 

14.  Masood Ahmad Rizvi, Mehvash Zaki, Mohd. Afzal, Manoj Mane, Manjeet Kumar, Bhahwal Ali Shah, Saurabh Srivastav, Saripella Srikrishna, Ghulam Mustafa Peerzada, Sartaj Tabassum. (2015) Nuclear blebbing of biologically active organoselenium compound towards human cervical cancer cell (HeLa): In vitro DNA/HSA binding, cleavage and cell imaging studies. European Journal of Medicinal Chemistry, 90 (2015) 876-888.

 

15.  Rahman Alizadeh, Imtiyaz Yousuf, Mohd Afzal, Saurabh Srivastav, Saripella Srikrishna, Farukh Arjmand (2015) Enantiomeric fluoro-substituted benzothiazole Schiff base-valine Cu(II)/Zn(II) complexes as chemotherapeutic agents: DNA binding profile, cleavage activity, MTT assay and cell imaging studies. Journal of Photochemistry and Photobiology B: Biology, 143, 61�73.

 

16.  Sartaj Tabassum, Mehvash Zaki, Musheer Ahmad, Mohd Afzal, Saurabh Srivastav, Saripella Srikrishna, Farukh Arjamnd (2014) Synthesis and crystal structure determination of copper(II)-complex: In vitro DNA and HSA binding, pBR322 plasmid cleavage, cell imaging and cytotoxic studies. European Journal of Medicinal Chemistry, 83, 141-154 (DOI: 10.1016/j.ejmech.2014.06.018).

 

17.  Sandeep Kumar Singh, Ruchi Gaur, Akhil Kumar, Roshan Fatima, Lallan Mishra and Saripella Srikrishna* (2013) Neuroprotective activity of 2-(4′-benzyloxyphenyl)-3-hydroxy-chromen-4-one against Aβ42 induced Neurodegeneration by in silico and in vivo studies in Alzheimer�s model of Drosophila. Neurotoxicity Research, 26 (4), 331-350.

 

18.  Sandeep Kumar Singh, Priti Sinha, L.Mishra and Saripella Srikrishna* (2013) Neuroprotective role of novel Copper chelator against Aβ42 induced Neurotoxicity. International Journal of Alzheimer�s Disease, (doi: 10.1155/2013/567128. Epub 2013 Sep 18).

 

19.  Prem Prakash Solanki, S Paul, A Pandey, H Sabia, U P Shahi and S Srikrishna (2014) To enhance the knowledge, awareness about the risk factor and screening practices of breast cancer among women in holy city Varanasi. J Cancer Sci Ther 2014, 6:9 (doi: 10.4172/1948-5956.S1.038).

20.  Shatabdi Paul1, Prem Prakash Solanki1, Uday Pratap Shahi, Saripella Srikrishna (2015) Epidemiological study on breast cancer associated risk factors and screening practices among women in the holy city of Varanasi, Uttar Pradesh, India. Asian Pac J Cancer Prev, 16, 8163-171.

21.  Rakesh Kumar Gupta, Rampal Pandey, Gunjan Sharma, Ritika Prasad, Pi-Zou Li, Q. Xu, Biplob Koch, Saripella Srikrishna and Daya Shankar Pandey (2013) DNA binding and anti cancer activity of Heteroleptic Piano Stool Ru(II), Rh(III) and Ir(III) Complexes Based on 4-(2-Methoxypyridyl)-phenyldipyrromethene. InorganicChemistry, 52(7):3687-98.

 

22.  Sartaj Tabassum, Ahmad Asim, Rais Ahmad Khan, Zahid Hussain, Saurabh Srivastav, Saripella Srikrishna and Farukh Arjmand (2013) Chiral Heterobimetallic Complexes Targeting Human DNA-Topoisomerase Iα. Dalton Transactions, 28; 42(48):16749-61.

 

23.  Sandeep Kumar Singh, Priti Sinha, P. Nagarajuna Reddy, Lallan Mishra and Saripella Srikrishna* (2012) Neuroprotective role of a novel Copper chelator (Amidoamine derivative) against Aβ42 induced Neurotoxicity in Drosophila model of Alzheimer�s disease. Annals of Neuroscience, 19, Suppl, 74.

 

24.  Flora L. Thorp-Greenwood, Michael P. Coogan, Lallan Mishra, Niraj Kumari, Geeta Rai and Srikrishna Saripella (2012) The Importance of Cellular Localisation of Probes: Synthesis, Photophysical Properties, DNA Interactions And Cellular Imaging Properties Of Rhenium Dppz Complexes With Known Cellular Localisation Vectors. New Journal of Chemistry, 36, 64-72. (Cover page article).

 

25.  Niraj Kumari, Brajesh Kumar Maurya, Raj Kumar Koiri, Surendra Kumar Trigun, Srikrishna Saripella, Mike Coogan and Lallan Mishra. (2011) Cytotoxic activity, cell imaging and Photocleavage of DNA induced by a Pt(II) cyclophane bearing 1, 2 diamino ethane as a terminal ligand. Med.Chem.Commun, 2, 1208- 1216 (DOI:10.1039/C1MD00159K).

 

26.  Bajpai S, Mishra M, Kumar H, Tripathi K, Singh SK, Srikrishna S, Pandey HP, and Singh RK. (2010) Comparative study of connexins expression in diabetic and non-diabetic wounds. Digest Journal of Nanomaterials and Biostructures. 5(3):857-862.

 

27.  Bajpai S. Shukla, V.K., Tripathi, K, Srikrishna, S and Singh R. K. (2009) Targeting connexin 43 in diabetic wounds: future perspectives. Journal of Post Graduate Medicine. 55:143-149.

 

28.  Sandeep Kumar Singh, Saripella Srikrishna*, Rudy J. Castellani, George Perry Antioxidants in the prevention and treatment of Alzheimer�s disease in: Nutritional Antioxidant Therapies: treatments and perspectives, Springer-Verlag (Germany). (In Press).