Faculty

S. C. Gupta


Assistant Professor
Ph. D. (Univ. Lucknow)
Contact Information:
Phone: +91-542-6701602; Cell:+91 9628197432 Fax: +91-0542-2368174 (Univ) Email Id: [email protected], [email protected]

Academic Qualifications:
S. No.DegreeInstitutionYear
1.M.Sc. Univ. of Lucknow2001
2.Ph.D.Univ. of Lucknow 2008
Area of Specialization: Cancer Biology, Cardiovascular Research, Molecular Pharmacology, Molecular Toxicology

Current research interests:
Current research is focused on uncovering the mechanism by which acidic micro-environment promote cancer growth. The focus of the laboratory is also on cancer chemoprevention and on other projects to understand the role of cancer stem cells, exosomal microRNAs and long non-coding RNAs in regulating tumor development. The major research interests of the laboratory can be broadly categorized in to following areas:

  • 1. Acidic Microenvironment and Tumor Invasion and Metastasis: The laboratory is interested to address several questions on the functions of a neuron specific acid sensing ion channel 1 in acidic microenvironment. The laboratory is also interested to dissect the signaling pathways associated with epithelial to mesenchymal transition in acidic microenvironment.

  • 2. Non-coding RNA as a molecular signature of tumor development: We are developing non-coding RNA based bio-markers for the diagnosis and prognosis of breast, pancreatic, head and neck, gallbladder and colorectal cancer.

  • 3. Regulation of NF-kB pathway by lncRNAs: The laboratory is interested to dissect the mechanism by which long non-coding RNAs regulate pro-inflammatory transcription factor nuclear factor (NF)-?B in cancer cells.

  • 4. Role of calcium in tumor development: Our focus is to elucidate the functions of calcium handling proteins such as sarcolipin, phospholamban and sarco (endo) plasmic reticulum Ca2+ ATPase in tumor development.

  • 5. Multi-targeting approach for the prevention and treatment of cancer: We are using nutraceuticals and ayurvedic formulations for the prevention, treatment and sensitization of tumor cells to chemotherapeutic agents.

  • 6. Drosophila as an in vivo model and tool for human cancer: We are using Drosophila as an in vivo tool to study cancer metabolism and for cancer drug development.

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    Contact Informations:
    Office:
    Department of Biochemistry
    Institute of Science
    Banaras Hindu University, Varanasi-221005, U.P.,INDIA
    Phone: +91-542-670 1602; Cell:+91 9628197432 Fax: +91-0542-2368174 (Univ)
    E-mail: [email protected], [email protected]

     
    Current Research Projects:
    S. No. Name of the Current Project Duration Source Amount (in Rs)
    1. Role of long non-coding RNAs in breast cancer invasion in acidic microenvironment2016-2019Science and Engineering Research Board, IndiaRs. 50.0 Lacs
    2.Chemosensitization of pancreatic cancer by a limonoid2016-2018UGC, New DelhiRs. 10.0 Lacs
    3.Designing a cell based prototype for the high throughput screening of cancer drugs 2016-2017Design and Innovation Center, BHU, IndiaRs. 5.0 Lacs
     
    Honours/Awards (National/ International):

    1. 1. Early Career Research Award by Science and Engineering Research Board, India (2016).

    2. 2. Recognized Reviewer, Food and Chemical Toxicology, Elsevier Publishers (2016).

    3. 3. Recognized Reviewer, Chemico-Biological Interactions, Elsevier Publishers (2016).

    4. 4. AAPS Journal Manuscript Award (2015).

    5. 5. Outstanding Reviewer, Life Sciences, Elsevier Publishers(2014).

    6. 6. Recognized Reviewer, Free Radical Biology and Medicine, Elsevier Publishers (2014).

    7. 7. National Eligibility Test (CSIR-UGC-NET) by University Grant commission, India (2003).

    8. 8. Junior Research Fellowship by Council of Scientific and Industrial Research, India (2003).

    9. 9. Junior Research Fellowship by Indian Council of Medical Research, India(2002).

    List of 10 major Publications:

    1. 1. Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY. Regulation of breast tumorigenesis through acid sensors. Oncogene. 2015, PMID: 26686084. IF: 8.459.

    2. 2. Gupta SC, Singh R, Pochampally R, Watabe K, Mo YY. Acidosis Promotes Invasiveness of Breast Cancer Cells Through ROS-AKT-NF-kB Pathway. Oncotarget. 5 (2014): 12070-12082. IF: 6.359.

    3. 3. Gupta SC, Francis SK, Nair MS, Mo YY, Aggarwal BB. Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to TRAIL through a p53-Independent Mechanism: Evidence for the Role of the ROS-ERK-CHOP-Death Receptor Pathway. The Journal of Biological Chemistry. 288 (2013): 32343-32356. IF: 4.573

    4. 4. Gupta SC, Prasad S, Sethumadhavan DR, Nair MS, Mo YY, Aggarwal BB. Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment. Clinical Cancer Research. 19 (2013): 4465-4476. IF: 8.722.

    5. 5. Gupta SC, Sung B, Prasad S, Webb LJ, Aggarwal BB, Cancer Drug Discovery by Repurposing: Teaching New Tricks to Old Dogs. Trends in Pharmacological Sciences. 34 (2013): 508-517. IF: 11.539.

    6. 6. Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh S, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD, Periasamy M. Sarcolipin is a novel regulator of muscle based thermogenesis in mammals. Nature Medicine. 18 (2012): 1575-1579. ($equal contribution). IF: 27.363.

    7. 7. Aggarwal BB, Gupta SC, Kim JH. Historical perspectives on tumor necrosis factor and its superfamily: twenty-five years later, a golden journey. Blood. 119 (2012): 651-665. IF: 10.452.

    8. 8. Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. The Journal of Biological Chemistry. 285 (2010): 35406-35417. IF: 4.573.

    9. 9. Bal NC, Sharon A, Gupta SC, Jena N, Shaikh S, Gyorke S, Periasamy M. The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization. The Journal of Biological Chemistry. 285 (2010): 17188-17196. IF: 4.573.

    10. 10. Gupta SC, Siddique HR, Saxena DK and Chowdhuri DK. Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): Induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinestearse. Biochimica et Biophysica Acta; 1725 (2005): 81-92. IF: 4.381.

    A. Full List of Publications :

    1. 1. Yadav A, Srikrishna S, Gupta SC. Cancer Drug Development using Drosophila as an in-vivo Tool: From Bedside to Bench and Back. Trends in Pharmacological Sciences, 2016, in press. IF: 11.539.

    2. 2. Prasad S$, Gupta SC$, Tyagi A, Aggarwal BB. Gamma-Tocotrienol Suppresses Growth and Sensitizes Human Colorectal Tumors to Capecitabine in a Nude Mouse Xenograft Model by Down-regulating Multiple Molecules. British Journal of Cancer, 2016, in press. ($equal contribution).

    3. 3. Prasad S, Gupta SC, Tyagi AK. Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Letters, 2016, PMID: 27037062. IF: 5.621.

    4. 4. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, Atfi A, Watabe K, Lu Z, Mo YY. Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Cell Death and Disease, 2016, in press. IF: 5.014

    5. 5. Prasad S, Gupta SC, Tyagi AK. Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Letters, 2016, PMID: 27037062. IF: 5.621.

    6. 6. Sahebkar A, Simental-Mendia LE, Cicero AFG, Aggarwal BB, Gupta SC. Curcumin Downregulates Human Tumor Necrosis Factor-a Levels: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 2016, PMID: 27025786. IF: 4.408.

    7. 7. Prasad S, Gupta SC, Aggarwal BB. Serendipity in Cancer Drug Discovery: Rational or Coincidence? Trends in Pharmacological Sciences, 2016, in press. IF: 11.539.

    8. 8. Prasad S, Yadav VR, Sung B, Gupta SC, Tyagi AK, Aggarwal BB. Ursolic Acid Inhibits the Growth of Human Pancreatic Cancer and Enhances the Antitumor Potential of Gemcitabine in an Orthotopic Mouse Model Through Suppression of the Inflammatory Microenvironment. Oncotarget, 2016, PMID: 26909608. IF: 6.359.

    9. 9. Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY. Regulation of breast tumorigenesis through acid sensors. Oncogene. 2015, PMID: 26686084. IF: 8.459.

    10. 10. Gupta SC, Singh R, Pochampally R, Watabe K, Mo YY. Acidosis Promotes Invasiveness of Breast Cancer Cells Through ROS-AKT-NF-?B Pathway. Oncotarget. 5 (2014): 12070-12082. IF: 6.359.

    11. 11. Han JG, Gupta SC, Prasad S, Aggarwal BB. Piperlongumine Chemosensitizes Tumor Cells Through Interaction with Cysteine 179 of I?Ba Kinase, Leading to Suppression of NF-?B-regulated Gene Products. Molecular Cancer Therapeutics. 13 (2014): 2422-2435. IF: 5.683.

    12. 12. Prasad S, Kim JH, Gupta SC, Aggarwal BB. Targeting Death Receptors by Agents Designed by Mother Nature. Trends in Pharmacological Sciences. 35 (2014): 520-536. IF: 11.539.

    13. 13. Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB. Downregulation of Tumor Necrosis Factor and Other Proinflammatory Biomarkers by Polyphenols. Archives of Biochemistry and Biophysics. 559 (2014): 91-99. IF: 3.017.

    14. 14. Prasad S, Gupta SC, Tyagi AK, Aggarwal BB, Curcumin, a component of golden spice: From bedside to bench and back. Biotechnology Advances. 32 (2014): 1053-1064. IF: 9.015.

    15. 15. Gupta SC, Francis SK, Nair MS, Mo YY, Aggarwal BB. Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to TRAIL through a p53-Independent Mechanism: Evidence for the Role of the ROS-ERK-CHOP-Death Receptor Pathway. The Journal of Biological Chemistry. 288 (2013): 32343-32356. IF: 4.573.

    16. 16. Gupta SC, Prasad S, Sethumadhavan DR, Nair MS, Mo YY, Aggarwal BB. Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment. Clinical Cancer Research. 19 (2013): 4465-4476. IF: 8.722.

    17. 17. Bombardier E, Smith IC, Gamu D, Fajardo VA, Vigna C, Sayer RA, Gupta SC, Bal NC, Periasamy M, Tupling AR. Sarcolipin Trumps beta Adrenergic Receptor Signaling as the Favored Mechanism for Muscle-Based Diet-Induced Thermogenesis. FASEB Journal. 27 (2013): 3871-3878. IF: 5.043.

    18. 18. Sung B$, Prasad S$, Yadav VR, Gupta SC, Reuter S, Yamamoto N, Murakami A, Aggarwal BB. RANKL Signaling and Osteoclastogenesis is Negatively Regulated by Cardamonin, PLOS One. 8 (2013): e64118. ($equal contribution). IF: 3.234.

    19. 19. Gupta SC, Phromnoi K, Aggarwal BB. Morin inhibits STAT3 Tyrosine 705 Phosphorylation in Tumor Cells Through Activation of Protein Tyrosine Phosphatase SHP1. Biochemical Pharmacology. 85 (2013):898-912. IF: 5.009.

    20. 20. Gupta SC, Sung B, Prasad S, Webb LJ, Aggarwal BB, Cancer Drug Discovery by Repurposing: Teaching New Tricks to Old Dogs. Trends in Pharmacological Sciences. 34 (2013): 508-517. IF: 11.539.

    21. 21. Aggarwal BB, Yuan W, Li S, Gupta SC, Curcumin-Free Turmeric Exhibits Anti-inflammatory and Anticancer Activities: Identification of Novel Components of Turmeric. Molecular Nutrition and Food Research. 57 (2013): 1529-1542. IF: 4.603.

    22. 22. Aggarwal BB, Gupta SC, Sung B. Curcumin: An Orally Bioavailable Blocker of TNF and Other Pro-inflammatory Biomarkers. British Journal of Pharmacology. 169 (2013): 1672-1692. IF: 4.842.

    23. 23. Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. BioFactors. 39 (2013): 2-13. IF: 4.592.

    24. 24. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: Lessons learned from clinical trials. The AAPS Journal. 15 (2013): 195-218. IF: 3.799.

    25. 25. Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multi-targeting by turmeric, the golden Spice: From kitchen to clinic. Molecular Nutrition and Food Research. 57 (2013): 1510-1528. IF: 4.603.

    26. 26. Bal NC, Maurya SK$, Sopariwala DH$, Sahoo SK, Gupta SC, Shaikh S, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD, Periasamy M. Sarcolipin is a novel regulator of muscle based thermogenesis in mammals. Nature Medicine. 18 (2012): 1575-1579. ($equal contribution). IF: 27.363.

    27. 27. Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB. Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-kB and NF-?B-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Molecular Nutrition and Food Research. 56 (2012): 454-465. IF: 4.603.

    28. 28. Kim JH, Park B, Gupta SC, Kannappan R, Sung B, Aggarwal BB. Zyflamend Sensitizes Tumor Cells to TRAIL-Induced Apoptosis Through Upregulation of Death Receptors and Downregulation of Survival Proteins: Role of ROS-Dependent CCAAT/enhancer-binding Protein-homologous Protein Pathway. Antioxidants and Redox Signaling. 16 (2012): 413-427. IF: 7.407.

    29. 29. Reuter S, Gupta SC, Phromnoi K, Aggarwal BB. Thiocolchicoside Suppresses Osteoclastogenesis Induced by RANKL and Cancer Cells Through Inhibition of Inflammatory Pathways: A New Use for an Old Drug. British Journal of Pharmacology. 165 (2012): 2127-2139. IF: 4.842.

    30. 30. Gupta SC, Hevia D, Patchva S, Park B, Koh W, Aggarwal BB. Upsides and downsides of ROS for cancer: The roles of ROS in tumorigenesis, prevention, and therapy. Antioxidants and Redox Signaling. 16 (2012): 1295-1322. IF: 7.407.

    31. 31. Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of the golden spice, and its miraculous biological activities. Clinical and Experimental Pharmacology and Physiology. 39 (2012): 283-299. IF: 2.372.

    32. 32. Aggarwal BB, Gupta SC, Kim JH. Historical perspectives on tumor necrosis factor and its superfamily: twenty-five years later, a golden journey. Blood. 119 (2012): 651-665. IF: 10.452.

    33. 33. Kannappan R, Gupta SC, Kim JH, Aggarwal BB. Tocotrienols fight cancer by targeting multiple cell signaling pathways. Genes and Nutrition. 7 (2012): 43-52. IF: 2.794.

    34. 34. Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Bharangin, a Diterpenoid Quinonemethide, Abolishes Constitutive and Inducible Nuclear Factor-kappa B Activation by Modifying p65 on Cysteine 38 Residue and Reducing Inhibitor of Nuclear Factor-kappaB alpha Kinase Activation, Leading to Suppression of NF-kappa B-Regulated Gene Expression and Sensitization of Tumor Cells to Chemotherapeutic Agents. Molecular Pharmacology. 80 (2011): 769-781. IF: 4.128.

    35. 35. Aggarwal BB, Prasad S, Yadav VR, Park B, Kim JH, Gupta SC, Yoon SW, Lavasanifar A, Sung B. Targeting inflammatory pathways by dietary agents for prevention and therapy of cancer. Journal of Food and Drug Analysis. 20 (2012): 231-236.

    36. 36. Tupling AR, Bombardier E, Gupta SC, Hussain D, Vigna C, Bloemberg D, Quadrilatero J, Trivieri MG, Babu GJ, Backx PH, Periasamy M, MacLennan DH, Gramolini AO. Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice. American Journal of Physiology-Cell Physiology. 301 (2011): C841-C849. IF: 3.780.

    37. 37. Gupta SC, Prasad S, Kim JH, Patchva S, Webb LJ, Priyadarsini IK, Aggarwal BB. Multitargeting by curcumin as revealed by molecular interaction studies. Natural Product Reports. 28 (2011): 1937-1955. IF: 10.107.

    38. 38. Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB. Role of nuclear factor kB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Experimental Biology and Medicine (Maywood). 236 (2011): 658-671. IF: 2.165

    39. 39. Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadev VR, Park B, Kim JH, Gupta SC, Phromnoi K, Sundaram C, Prasad S, Chaturvedi MM, Sung B. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach. Current Drug Targets. 12 (2011): 1595-1653. IF: 2.794.

    40. 40. Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB. Epigenetic changes induced by curcumin and other natural compounds. Genes and Nutrition. 6 (2011): 93-108. IF: 2.794.

    41. 41. Kannappan R, Gupta SC, Kim JH, Reuter S, Aggarwal BB. Neuroprotection by spice-derived nutraceuticals: you are what you eat! Molecular Neurobiology. 44 (2011): 142-159. IF: 5.137.

    42. 42. Gupta SC, Kannappan R, Reuter S, Kim JH, Aggarwal BB. Chemosensitization of tumors by resveratrol. Annals of the New York Academy of Sciences. 1215 (2011): 150-160. IF: 4.384.

    43. 43. Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. The Journal of Biological Chemistry. 285 (2010): 35406-35417. IF: 4.573.

    44. 44. Bal NC, Sharon A, Gupta SC, Jena N, Shaikh S, Gyorke S, Periasamy M. The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization. The Journal of Biological Chemistry. 285 (2010): 17188-17196. IF: 4.573.

    45. 45. Gupta SC, Mishra M, Sharma A, Deepak Balaji TG, Kumar R, Mishra RK, Chowdhuri DK. Chlorpyrifos induces apoptosis and DNA damage in Drosophila through generation of reactive oxygen species. Ecotoxicology and Environmental Safety. 73 (2010): 1415-1423. IF: 2.762.

    46. 46. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biology and Medicine. 49 (2010): 1603-1616. IF: 5.736.

    47. 47. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer and Metastasis Reviews. 29 (2010): 405-434. IF: 7.234.

    48. 48. Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-kB activation by small molecules as a therapeutic strategy. Biochimica et Biophysica Acta. 1799 (2010): 775-787. IF: 6.332.

    49. 49. Gupta SC, Sharma A, Mishra M, Mishra RK, Chowdhuri DK. Heat shock proteins in toxicology: how close and how far? Life Sciences. 86 (2010): 377-384. IF: 2.702.

    50. 50. Gupta SC, Varian KD, Bal NC, Abraham JL, Periasamy M and Janssen PML. Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits. American Journal of Physiology: Heart and Circulatory Physiology 296 (2009): H1933-H1939. IF: 3.838.

    51. 51. Varian KD, Kijtawornrat A, Gupta SC, Torres CAA, Monasky MM, Hiranandani N, Delfin DA, Rafael-Fortney JA, Periasamy M, Hamlin RL and Janssen PML. Impairement of Diastolic Function by Lack of Frequency-Dependent Myofilament Desensitization in Rabbit Right Ventricular Hypertrophy. Circulation-Heart Failure 2 (2009): 472-481. IF: 5.891.

    52. 52. Siddique HR, Gupta SC, Mitra K, Bajpai VK, Mathur N, Murthy RC, Saxena DK and Chowdhuri DK. Adverse effect of tannery waste leachates in transgenic Drosophila melanogaster: Role of ROS in modulation of Hsp70, oxidative stress and apoptosis. Journal of Applied Toxicology 28 (2008): 734-748. IF: 2.982.

    53. 53. Siddique HR, Sharma A, Gupta SC, Murthy RC, Dhawan A, Saxena DK and Chowdhuri DK. DNA damage induced by industrial solid waste leachates in Drosophila melanogaster: a mechanistic approach. Environmental and Molecular Mutagenesis 49 (2008): 206-216. IF: 2.630.

    54. 54. Gupta SC, Siddique HR, Mathur N, Vishwakarma AL, Mishra RK, Saxena DK and Chowdhuri DK. Induction of hsp70, alterations in oxidative stress markers and apoptosis against dichlorvos exposure in transgenic Drosophila melanogaster: modulation by reactive oxygen species. Biochimica et Biophysica Acta 1770 (2007): 1382-1394. IF: 4.381.

    55. 55. Gupta SC, Siddique HR, Mathur N, Mishra RK, Mitra K, Saxena DK and Chowdhuri DK. Adverse effect of organophosphate compounds dichlorvos and chlorpyrifos in the reproductive tissues of transgenic Drosophila melanogaster: 70 kDa heat shock protein as a marker of cellular damage. Toxicology 238 (2007): 1-14. IF: 3.621.

    56. 56. Siddique HR, Gupta SC, Mitra K, Murthy RC, Saxena DK and Chowdhuri DK. Induction of biochemical stress markers and apoptosis in transgenic Drosophila melanogaster against complex chemical mixtures: Role of reactive oxygen species. Chemico-Biological Interaction 169 (2007): 171-188. IF: 2.577.

    57. 57. Gupta SC, Siddique HR, Saxena DK and Chowdhuri DK. Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): Induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinestearse. Biochimica et Biophysica Acta; 1725 (2005): 81-92. IF: 4.381.

    58. 58. Gupta SC, Siddique HR, Saxena DK and Chowdhuri DK. Comparative toxic potential of market formulation of two organophosphate pesticides in transgenic Drosophila melanogaster (hsp70-lacZ). Cell Biology and Toxicology; 21 (2005): 149-162. IF: 2.677.

    59. 59. Siddique HR, Gupta SC, Dhawan A, Murthy RC, Saxena DK and Chowdhuri DK. Genotoxicity of industrial solid waste leachates in Drosophila melanogaster. Environmental and Molecular Mutagenesis; 46 (2005): 189-197. IF: 2.630.

    B. Chapter in Books:

    1. 1. Aggarwal BB, Kunnumakkara AB, Gupta SC. Curcumin as an example of holistic targeting agent. In: Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting, Editors: Patwardhan B and Chaguturu R, Elsevier Inc., Philadelphia, USA, 2016, in press.

    2. 2. Aggarwal BB, Gupta SC. Wonders of curcumin: haldi is healthy for jaldi recovery. In: Text Book of Biochemistry, Biotechnology, Allied and Molecular Medicine, edited by Talwar GP, Hasnain SE and Sarin SK, PHI Learning Private Limited, Delhi, India, 2016, Fourth edition, Chapter 127, pp 1434-1439.

    3. 3. Aggarwal BB, Prasad S, Sung B, Gupta SC. Anti-inflammatory lifestyle and spices: How are they linked? In: Text Book of Biochemistry, Biotechnology, Allied and Molecular Medicine, edited by Talwar GP, Hasnain SE and Sarin SK, PHI Learning Private Limited, Delhi, India, 2016, Fourth edition, Chapter 126, pp 1424-1433.

    4. 4. Prasad S, Gupta SC, Sung B, Aggarwal BB. Modulation of Proteasome Pathways by Nutraceuticals. In: Cancer Chemoprevention and Treatment by Diet Therapy, Series: Evidence-based Anticancer Complementary and Alternative Medicine, Editors: Cho WCS, Springer Press, Spring Street, NY, 2013, Vol. 5, pp 233-267.

    5. 5. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Chronic inflammation and cancer: a matter of lifestyle. In: Chronic inflammation: nutritional and therapeutic interventions, Editors: Roy S, Bagchi D, Raychaudhuri SP. CRC Press, Taylor and Francis Group, Boca Raton, NY, 2012, pp. 153-171.

    6. 6. Prasad S, Gupta SC, Aggarwal BB. Micronutrients and cancer: add spice to your life. In: Nutrition, diet and cancer, edited by Srivastava R. Springer Press, Spring Street, NY, 2012, pp. 23-48.

    7. 7. Prasad S, Sung B, Patchva S, Gupta SC, Aggarwal BB. Tocotrienols, inflammation, and cancer: how are they linked? In: Tocotrienols: vitamin E beyond tocopherols, Editors: Watson RR and Preedy VR. CRC Press, Taylor and Francis Group, Boca Raton, NY, 2012, pp. 209-223.

    8. 8. Sung B, Prasad S, Gupta SC, Patchva S, Aggarwal BB. Regulation of Inflammation-Mediated Chronic Diseases by Botanicals. In: Recent Trends in Medicinal Plants Research, Editors: Shyur L-F and Lau ASY. Advances in Botanical Research, Elsevier book series, 2012, Volume 62, pp. 57-132.

    9. 9. Aggarwal BB, Sundaram C, Prasad S, Reuter S, Kannappan R, Yadav VR, Park B, Kim JH, Gupta SC, Phromnoi K, Sung B. Chronic diseases caused by chronic inflammation require chronic treatment: the anti-inflammatory lifestyle. In: Inflammation, lifestyle, and chronic disease the silent link, Editors: Aggarwal BB, Krishnan S, Guha S. CRC Press, Taylor and Francis Group, Boca Raton, NY, 2011, pp. 373-446.

    C. Invited talks and presentations:

    1. 1. Gupta SC. NF kB as a Therapeutic Target for Cancer Therapy: Potential of a Nutraceutical. International Conference on Recent Advances in Food Processing and Biotechnology. Banaras Hindu University, Varanasi, 221005, India; April 05-06, 2016.

    2. 2. Gupta SC. Targeting inflammatory pathways by a small molecule for the prevention and treatment of Cancer. Department of Chemistry, Institute of Science, Banaras Hindu University and the local chapter of the Chemical Research Society of India (Varanasi), India; March 12, 2016.

    3. 3. Gupta SC, Mo YY. Acidic microenvironment and breast cancer growth: A vicious connection. 6th International Translational Cancer Research Conference on Prevention and Treatment of Cancer: Hypes and Hopes. Hyatt Regency, Ahmedabad, Gujarat, India; February 04-07, 2016.

    4. 4. Gupta SC. Regulation of breast tumorigenesis through acid sensors. Mini-symposium at Interdisciplinary School of Life Sciences, Institute of Science, Banaras Hindu University, India; January 30, 2016.

    5. 5. Gupta SC. Acidic microenvironment and tumor growth: A vicious connection. Department of Bio-chemistry, Institute of Science, Banaras Hindu University, India; November 30, 2015.

    6. 6. Gupta SC, Mo YY. MALAT1 is crucial for epithelial-mesenchymal transition of breast cancer cells in acidic microenvironment. 106th Annual Meeting of the American Association for Cancer research, Philadelphia, Pennsylvania, USA; April 18-22, 2015 Published in Cancer Research 75 (15 Suppl-2015): Abstract nr 168. doi:10.1158/1538-7445.AM2015-168.

    7. 7. Gupta SC, Mo YY. Acidosis-induced NF-?B promotes cell invasion in breast cancer. 105th Annual Meeting of the American Association for Cancer research, San Diego, California, USA; April 05-09, 2014 Published in Cancer Research 74 (19 Suppl-2014): Abstract nr 1101. doi:10.1158/1538-7445.AM2014-1101 .

    8. 8. Bal NC, Sharon A, Gupta SC, Jena N, Gyorke S, Periasamy M. An alternately charged residue cluster at the N-terminal end forms a ring system and dynamically regulates calsequestrin polymerization. Biophysical Journal. 98 (2010): 234.

    9. 9. Varian KD, Kijtawornrat A, Gupta SC, Torres CAA, Monasky MM, Hiranandani N, Periasamy M, Hamlin RL, Janssen PML. Frequency dependent myofilament desensitization is impaired in rabbit right ventricular hypertrophy. The FASEB Journal. 23 (2009): 953.1.

    10. 10. Gupta SC, Bal NC, Bombardier E, Tupling AR, Periasamy M. Ablation of SLN increases susceptibility to diet-induced obesity and alters metabolism in mice. 24th Annual Meeting of Ohio Physiological Society, The Ohio State University, USA; October 29-30, 2009.

    11. 11. Bal NC, Sharon A, Gupta SC, Shaikh S, Gyorke S, Periasamy M. R33Q disrupts the molecular switch at the N-terminal end hindering the dynamicity of calsequestrin plomerization. 24th Annual Meeting of Ohio Physiological Society, The Ohio State University, USA; October 29-30, 2009.

    12. 12. Bal NC, Gupta SC, Bombardier E, Sayer RA, Norris SM, Tupling AR, Periasamy M. Sarcolipin is a novel regulator of metabolism and obesity. 27th Annual Scientific Meeting of the Obesity Society, Washington DC, USA; October 24-28, 2009.

    13. 13. Gupta SC, Varian KD, Bal NC, Abraham JL, Periasamy M, Janssen PML. Altered expression of Ca2+-transport proteins of the right atrium following pulmonary artery banding in the rabbit. 8th Annual OSUMC Research Day, The Ohio State University, USA; April 02, 2009.

    14. 14. Gupta SC, Varian KD, Bal NC, Abraham JL, Periasamy M, Janssen PML. Right ventricular pressure overload affects right atrial Ca2+-transport protein expression in rabbit hearts. 3rd Annual Physiology and Cell Biology Research Day, The Ohio State University, USA; March 06, 2009.

    15. 15. Gupta SC, Siddique HR, Saxena DK and Chowdhuri DK. Organophosphates induced ROS generation modulates Hsp70 expression, anti-oxidant defense enzymes and programmed cell death in Drosophila. 30th All India Cell Biology Conference and Symposium, University of Delhi, India; February 02-04, 2007.

    16. 16. Chowdhuri DK, Siddique HR, Gupta SC and Saxena DK. Fly to Environment: Toxicological perspectives. 30th All India Cell Biology Conference and Symposium, University of Delhi, India; February 02-04, 2007.

    17. 17. Siddique HR, Bhargava D, Gupta SC, Saxena DK and Chowdhuri DK. Biomarkers of stress and cellular damage in Drosophila melanogaster: possible role of reactive oxygen species (ROS). EMBO International Workshop, IIT Kanpur India; December 16-20, 2006.

    18. 18. Gupta SC, Siddique HR, Singh MP, Saxena DK and Chowdhuri DK. Hazardous effect of organophosphate compound, chlorpyrifos in transgenic Drosophila melanogaster (hsp70-lac Z): Correlations among stress response, anti-oxidant defense system and cell death. 29th All India Cell Biology Conference and Symposium, IITR (CSIR) Lucknow, India; January 17-20, 2006.

    19. 19. Siddique HR, Gupta SC, Dhawan A, Murthy RC, Saxena DK and Chowdhuri DK. Genotoxicity of industrial solid waste leachates in Drosophila melanogaster: Influence of mus308, mus201, ligaseIV, mei41, rad54 and Dnase II mutations. 29th All India Cell Biology Conference and Symposium, IITR (CSIR) Lucknow, India; January 17-20, 2006.

    20. 20. Gupta SC, Siddique HR, Saxena DK and Chowdhuri DK. The study of correlation between stress response and antioxidant defense systems against xenobiotic toxicity. 28th All India Cell Biology Conference and Symposium, Punjab University, Chadigarh, India; December 1-3, 2004.

    21. 21. Siddique HR, Gupta SC, Dhawan A, Saxena DK and Chowdhuri DK. Detection of in vivo genotoxicity of leachates from industrial solid wastes in Drosophila melanogaster using modified alkaline Comet assay. 28th All India Cell Biology Conference and Symposium, Punjab University, Chandigarh, India; December 1-3, 2004.

    22. 22. Kar Chowdhuri D, Saxena DK, Dhawan A, Mukhopadhyay I, Nazir A, Siddique HR and Gupta SC. Drosophila melanogaster: An in vivo model for toxicity assessment. Workshop on Current Techniques in Genetic Toxicology. IITR, Lucknow, India, December 1-15, 2004.

    23. 23. Chowdhuri DK and Gupta SC. Soluble quantitative Assay in Drosophila: Use and Application in toxicological research. INDO-UK Workshop under INDIA-UK Science Networks, Banaras Hindu University, Varanasi, India; September 1-5, 2004.

    Additional Information/ Achievements:

    1. Positions and Employment

  • November 16, 2015-Present: Assistant Professor, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India.

  • June 13, 2016-July 01, 2016: Visiting Consultant, Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, USA

  • July 22, 2013-November 13, 2015: Instructor, Cancer Institute, Department of Bio-chemistry, University of Mississippi Medical Center, USA.

    • 2. Postgraduate training

  • January, 2013- July, 2013: Post-Doctoral Fellow II, Cancer Institute, University of Mississippi Medical Center, USA.

  • December, 2009- December 2012: Post-Doctoral Fellow, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, USA.

  • October, 2007- November 2009: Post-Doctoral Researcher, Department of Physiology and Cell Biology, The Ohio State University, USA.

  • 2016: Member, Editorial Board, Insights in Cancer Research

  • 2016: Member, Editorial Board, Journal of Pharmacy and Pharmacology

  • 2016: Member, Editorial Board, Journal of Biomedical research

  • 2016: Member, Editorial Board, Journal of Biotechnology and Molecular Biology

  • 2016: Guest Editor, Frontiers in Bioscience; Special Issue: Targeted Cancer Therapies: Hope and Hype

  • 2016: Co-editor of the book Anti-inflammatory Nutraceuticals and Chronic Diseases, Series: Advances in Experimental Medicine and Biology

  • 2016: Co-editor of the book Drug Discovery from Mother Nature, Series: Advances in Experimental Medicine and Biology

  • 2014: Co-editor of the book Inflammation and Cancer, Series: Advances in Experimental Medicine and Biology

  • 2014: Guest Editor, Oxidative Medicine and Cellular Longevity; Special Issue: Oxidative Stress and Cancer: Advances and Challenges, PMID: 27293513

  • 2013: Member, Editorial Board, Pharmacology Research and Perspectives

  • 2013: Associate Editor, Journal of Pharmacology Research

  • 2013: Guest Editor, Forum on Immunopathological Diseases and Therapeutics; Special Issue: NF-?B, Immune System and Chronic Diseases: How Are They Linked? 4 (2) (2013)

    • 3.Adhoc Reviewer:

  • Free Radical Biology and Medicine, International Journal of Cancer, Molecular Nutrition and Food Research, Life Sciences, PLOS ONE, Apoptosis, British Journal of Pharmacology, Biochimica et Biophysica Acta, Food and Chemical Toxicology, Theriogenology, Molecular Imaging, Chemical Biology and Drug Design, BMC Complementary and Alternative Medicine, Environmental Toxicology, The International Journal of Biochemistry and Cell Biology, Phytomedicine, Pharmaceutical Crops, Cancer Biotherapy and Radiopharmaceuticals, International Immunopharmacology, Journal of Biomedicine and Biotechnology, Marine Drugs, Translational Medicine: Current Research, Anti-Cancer Drugs, Journal of Molecular Medicine, Evidence-Based Complementary and Alternative Medicine, Journal of Biomolecular Structure and Dynamics, Pharmacology Research and Perspectives, BioMed Research International, International Journal of Genetics and Molecular Biology, Pharmaceutical Biology, Journal of Biological Inorganic Chemistry, MedChemComm, Chemico-Biological Interactions, BMC Cancer.

    • 4. Research support (completed):

  • 1. Acidic microenvironment promotes breast cancer invasion and metastasis, Agency: Intramural Research Support Program, UMMC, USA; period: 11/01/2013 to 10/31/2014 (Direct Cost Budget: USD 25,000.00)

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