Dr. SATHEESHKUMAR P. K.

Associate Professor
Ph.D. (M.K. University, Madurai)
Contact Information:
Tel. +91 9544576372, 7991567298 Fax:(+91 542) 2368174
Email Id:[email protected], [email protected]

 
 
Academic Qualifications:
 
S. No.DegreeInstitutionYear
1.M.Sc.M.G. University, Kottayam1997
2.Ph. D.M.K. University, Madurai2007
 
 
Professional Employments:

S. No.Name of the Post Name of the DepartmentName of the Inst./UnivDuration
6.Associate ProfessorBotany DepartmentBanaras Hindu University (India)November 2017-Present
5.Research AssociateBotany DepartmentUniversity of Kerala (India)October 2016-November 2017
4.Research ScientistJNTBGRI JNTBGRI, Trivandrum (India) March 2013-July 2016
3.Senior ScientistVIT, VelloreVIT, VelloreJuly 2008-Feb 2013
2.Post Doctoral Fellow Life Science DepartmentWeizmann Institute of Science (Israel)May 2006-May 2008
1.Guest LecturerDepartment of BotanyM.G. University, KottayamAugust 1998-March 2000
Area of specialization:
 

Plant tissue culture and transgenics, Plant Molecular biology, Recombinant protein expression in prokaryotic and eukaryotic systems.

 
Current Research Projects:
 

S. No.Name of the Project DurationSource of FundingAmount of Funding (Rs)
1. "Cost effiective production of recombinant human coagulation factor VIII (F-VIII) BT/01/COE/06/18" (P.I) 2018- 2021DBT, New Delhi lacs
 
List of 10 major Publications:
  1. Gunasekaran, D, Sikha, T, Pinto, SM, Kiran Kumar, M, Patel, K, Kumar M, Kumar V, Jebasingh T, Satheeshkumar PK, Gowda H, Prasad TSK and Madanan MG (2018) Proteomic approach and expression analysis revealed differential expression of leptospiral proteases capable of ECM degradation. BBA Proteins and Proteomics, 1866, 712-721.
  2. Anu, PV, Madanan, MG, Nair, AJ, Nair, GA, Nair, GM, Sudhakaran PR and Satheeshkumar PK (2018) Heterologous expression, purification and characterization of an Oligopeptidase A from the pathogen Leptospira interrogans. Mol. Biotechnol., 60-302-309
  3. Balaji, P, Satheeshkumar, PK, Krishnan V, and Vijayalakshmi, MA (2015) Expression of anti-Tumor Necrosis Factor alpha (TNFa) Single Chain Variable Fragment (scFv) in Spirodela punctata plants transformed with Agrobacterium tumefaciens; Biotechnol. Appl. Biochem. 63 (3), 354-361, doi: 10.1002/bab.1373
  4. Sudheer Reddy AR, Satheeshkumar PK and Vijayalakshmi MA (2013) Expression, purification, and partial in vitro characterization of biologically active human coagulation factor VIII light chain (A3-C1-C2) in Pichia pastoris, Journal of Appl. Biochem. Biotechnol., 17(1), 10-19 doi: 10.1007/s12010-013-0338-4
  5. Deepa M, Sureshkumar T, Satheeshkumar PK and Priya S (2013) Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the down- regulation of nitric oxide produced by inducible nitric oxide synthase, Nutr. Cancer, 65(2): 305-10.
  6. Deepa M, Sureshkumar T, Satheeshkumar PK and Priya S (2012) Purified mulberry leaf lectin induced apoptosis and cell cycle arrest in human colon and breast cancer cells through a caspase mediated pathway, Chemico-Biol. Interact., 200: 38-44.
  7. Priya S, Noor A and Satheeshkumar PK (2012) Antioxidant and anti-proliferative activity of different solvent extracts of Casuarina equistifolia needles, Int. J. Phytomed, 4(1), doi: 10.5138/ijpm.v4i1.516.
  8. Sushma K, Bilgimol CJ, Vijayalakshmi MA and Satheeshkumar PK (2012) Recovery of active anti TNF alpha ScFv through matrix-assisted refolding of bacterial inclusion bodies using CIM monolithic support, J. Chrom. B. 891-892: 90-93. doi:10.1016 /j.jchromb.2012. 02.011
  9. Sushma K, Vijayalakshmi MA, Krishnan V and Satheeshkumar PK (2011) Cloning, expression, purification and characterization of a Single chain variable fragment specific to Tumor Necrosis Factor Alpha in Escherichia coli, J. Biotechnol. 156: 238-244 doi:10.1016/j.jbiotec.2011. 06.039)
  10. Satheeshkumar PK, Murugiah V and Gupta AK (2009) In vitro multiplication of the multipurpose tree Casuarina equisetifolia., Linn. AJMBES, 11 (4), pp. 743-749
Patents:
  • Double mutant coagulation factor viii and methods thereof (US 20150337028 A1).
  • Methods for producing recombinant factor viii chains from non-filamentous fungi, their functional reconstitution and applications thereof (US 20150225472 A1).
     Full List of Publications:
    A. Referred Scientific Articles in International Journal of repute:
    1. Gunasekaran, D, Sikha, T, Pinto, SM, Kiran Kumar, M, Patel, K, Kumar M, Kumar V, Jebasingh T, Satheeshkumar PK, Gowda H, Prasad TSK, Madanan MG (2018) Proteomic approach and expression analysis revealed differential expression of leptospiral proteases capable of ECM degradation. BBA Proteins and Proteomics, 1866, 712-721.
    2. Satheeshkumar, PK, Anu, PV, Junaida, MI, Madanan, MG, Jebasingh, T, Nair, AJ, Nair, GA, Nair, GM and Sudhakaran PR (2018) Expression of Leptospira Membrane Proteins Signal Peptidase (SP) and Leptospira Endostatin like A (Len A) in BL-21(DE3) is toxic to the host cells, Journal of Genetic Engineering and Biotechnology, doi.org/10.1016/j.jgeb.2018.01.004
    3. Anu, PV, Madanan, MG, Nair, AJ, Nair, GA, Nair, GM, Sudhakaran PR and Satheeshkumar PK (2018) Heterologous expression, purification and characterization of an Oligopeptidase A from the pathogen Leptospira interrogans. Molecular Biotechnology, 60-302-309
    4. Balaji, P, Satheeshkumar, PK, Krishnan V, and Vijayalakshmi, MA (2016) Periplasmic secretion, extraction and purification of recombinant tagless anti-Tumor Necrosis Factor (TNF) alpha single chain variable fragment (scFv) in E. coli; International Journal of Current Research, 8(2), 26014-26019.
    5. Balaji, P, Satheeshkumar, PK, Krishnan V, and Vijayalakshmi, MA (2015) Expression of anti-Tumor Necrosis Factor alpha (TNFa) Single Chain Variable Fragment (scFv) in Spirodela punctata plants transformed with Agrobacterium tumefaciens; Biotechnology and Applied Biochemistry. 63 (3), 354-361, doi: 10.1002/bab.1373.
    6. Sudheer Reddy AR, Satheeshkumar PK and Vijayalakshmi MA (2013) Expression, purification, and partial in vitro characterization of biologically active human coagulation factor VIII light chain (A3-C1-C2) in Pichia pastoris, Journal of Applied Biochemistry and Biotechnology, 17(1), 10-19 doi: 10.1007/s12010-013-0338-4
    7. Deepa M, Sureshkumar T, Satheeshkumar PK and Priya S (2013) Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the down- regulation of nitric oxide produced by inducible nitric oxide synthase, Nutrition and Cancer, 65(2): 305-10.
    8. Deepa M, Sureshkumar T, Satheeshkumar PK and Priya S (2012) Purified mulberry leaf lectin induced apoptosis and cell cycle arrest in human colon and breast cancer cells through a caspase mediated pathway, Chemico-Biological Interaction, 200: 38-44.
    9. Priya S, Noor A and Satheeshkumar PK (2012) Antioxidant and antiproliferative activity of different solvent extracts of Casuarina equistifolia needles, International Journal of Phytomedicine, 4(1), doi: 10.5138/ijpm.v4i1.516.
    10. Sushma K, Bilgimol CJ, Vijayalakshmi MA and Satheeshkumar PK (2012) Recovery of active anti TNF alpha ScFv through matrix-assisted refolding of bacterial inclusion bodies using CIM monolithic support, Journal of Chromatography B. 891-892: 90-93. doi:10.1016 /j.jchromb.2012. 02.011
    11. Sushma K, Vijayalakshmi MA, Krishnan V and Satheeshkumar PK (2011) Cloning, expression, purification and characterization of a Single chain variable fragment specific to Tumor Necrosis Factor Alpha in Escherichia coli, Journal of Biotechnology, 156: 238-244 doi:10.1016/j.jbiotec.2011. 06.039)
    12. Sushma, K, Satheeshkumar, PK, Krishnan V, and Vijayalakshmi, MA, (2010) Recombinant anti TNF alpha scFv: A potential replacement candidate for anti TNF alpha molecules, Journal of Biotechnology, proceedings (150): 401
    13. Satheeshkumar PK, Murugiah V and Gupta AK (2009) In vitro multiplication of the multipurpose tree Casuarina equisetifolia., Linn. Asian Journal of Microbiology Biotechnology and Environmental Science, 11 (4), pp. 743-749
    14. Satheeshkumar PK, Murugiah, V and Gupta AK (2008) Isolation of good quality RNA from the woody species Casuarina equisetifolia., Linn. Asian Journal of Microbiology Biotechnology and Environmental Science, 10(4): 789-792
    15. Anoop N, Murugiah V, Satheeshkumar PK and Gupta AK (2007) Transgenic indica Rice expressing Codon - modified cry1Ac Gene confer resistance against Yellow Stem Borer larvae (Scirpophaga incertulas), Asian Journal of Microbiology Biotechnology and Environmental Science, 12: 74-79
    16. Satheeshkumar PK and Gupta AK (2006) In vitro plant regeneration and Transformation of woody tree species- a Review, J. Swamy Bot-Cl. 23: 43-62
    B. Papers published in Conference/Workshop/Meeting Articles:
    1. Anu, PV, Junaida, MI, Satheeshkumar, PK Madanan, MG, Nair AJ, Nair, GA, Nair GM and Sudhakaran, PR (2017) Analysis of Recombinant Expression of Two Transmembrane Proteins in Heterologous Expression System. In the National Seminar on Frontiers in Biotechnology Molecular, Epigenetic and Genomic research platforms in healthcare and food security conducted at University of Kerala, Kariavattom, March 1-3, 2017.
    2. Sudheer Reddy AR, Vijayalakshmi MA and Satheeshkumar PK, Secretory expression of the recombinant human factor viii light chain in Pichia pastoris, In the International conference on Molecular Medicine; Molmed-2012, held at , VIT University, Feb, 2012.
    3. Janarthanan S, Sushma K, Satheeshkumar PK and Vijayalakshmi, MA, Bioprocess strategies for production of anti TNF alpha scFv using recombinant Escherichia coli, In the international symposium on Bioprocess: Industry-Academia interaction, VIT University, July, 2011.
    4. Sushma K, Satheeshkumar P K, Krishnan V and Vijayalakshmi MA. Recombinant anti TNF-a ScFv: Cloning, expression and purification, in the international symposium organized by Society for Biochromatography and Nanoseparation, Lyon, France, Oct 2010
    5. Sushma K, Satheeshkumar P K, Krishnan V and Vijayalakshmi MA. Recombinant anti TNF-a ScFv: A potential replacement candidate for anti-TNF-a Antibodies, in the14th International Biotechnology Symposium and Exhibition, Biotechnology for the Sustainability and Human Society, Rimini Italy, Sept 2010
    6. Sushma K, Satheeshkumar P K, Krishnan V and Vijayalakshmi MA: Recombinant anti TNF-a ScFv: Cloning, expression and purification (presented in the International Symposium on Gene to Vial, Feb-2010 held ate CBST, VIT University and was awarded the prestigious SBCN award for the best oral presentation)
    7. Palani, B, Satheeshkumar PK and Vijayalakshmi, MA, Purification of a recombinant Histidine rich protein of Plasmodium falciparum in International Symposium on Gene to Vial-Concept for Biotechnology Based Health Care Molecules held during February 7 - 10, 2010 at VIT University, Vellore India.
    8. Jagadish SB, Balaji P, Vijayalakshmi MA and Satheeshkumar PK, In vitro multiplication of the duckweed Spirodela punctata (G. May) (poster presented in the national conference Biotechmeet 2010 held at Madurai Kamaraj University, Madurai, India)
    9. Satheeshkumar PK and Aditya K. Gupta. In vitro plant multiplication in Casuarina equisetifolia., Linn. Oral presentation at the National symposium on Arboriculture and Aquaculture, conducted at St George College Aruvithura, Mahathma Gandhi University, Kottayam, Kerala, July 25-27, 2005
    10. Satheeshkumar PK and Aditya K. Gupta, In vitro plant regeneration from axillary shoot explants in Casuarina equisetifolia., Linn. Poster presented at the national Symposium on New opportunities and Challenges for Improving Crop productivity through Biotechnology, conducted at CCS Haryana Agricultural University, Hisar, Feb. 13-15, 2002
    11. Satheeshkumar PK and Aditya K. Gupta. Genetic engineering of Casuarina equisetifolia Linn, for salinity and drought tolerance. Poster presented at the National Symposium on Relevance of Plant Biochemistry and Biotechnology-Modern Trends, conducted at The American College Madurai, by the Indian Society for Plant Biochemistry and Biotechnology, March 1-3, 2001
    C. Books/Book Chapters:
    1. Satheeshkumar PK and Anoop N (2016) Biopiracy; In Bioresources and Bioprocess in Biotechnology (Volume I - Status and Strategies for exploration), Sabu, A, Pradeep, N.S., Shiburaj, S (Eds.) Springer, ISBN 978-981-10-3573-9

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