Dr. Krishna Nand Singh

Professor of Organic Chemistry
Ph.D (BHU)
Dr. Krishna Nand Singh
Professor of Organic Chemistry
Department of Chemistry
Faculty of Science
Banaras Hindu University
Varanasi-221005, INDIA
Tel: 0542-2575196 (Res)
0542-6702485 (Off)
Fax: 0542-368127
Mobile: 09415992580
E-mail: [email protected]
[email protected] 		Employee No. 13673

Academic Qualifications:
 
Banaras Hindu University
S. No.DegreeInstitutionYear
1.B.Sc.Gorakhpur University 1981 
2.M.Sc. 1984 
3.Ph. D.Banaras Hindu University 1991 
Area of Specialization:
  • Development of New/Green Methodologies.
  • Microwave Assisted Organic Synthesis.
  • Transition Metal Catalyzed/Metal-free Reactions in Organic synthesis.
  • Multi-component Reactions in Organic Synthesis.
  • Heterocycles
Current Research Projects as Principal Investigator:
Agency Title Duration Amount in Rs. (lakh)
UGC Microwave assisted multicomponent synthesis of some important bio-active heterocycles July 01, 2011 to June 30, 2014 8.258
DBT Multicomponent Synthesis of Some Novel Biheterocyclic Medicinal Scaffolds under Controlled Microwave Irradiation July 2011 to June 2014 19.40
DST Development of green synthetic strategies for C-H functionalization of some aromatic and heteroaromatic molecules under controlled microwave June 2013-May 2016 38.40

Awards/ Recognitions if any:


Invited Professor, Institute of Chemistry, University of Rennes, France. (2004).

AICTE Career Award (1995).

Received Twelve Major Research Projects as Principal Investigator from UGC, CSIR, DBT, AICTE and DST, New Delhi.

Awarded Research Associateship (direct) of CSIR (1992).

Qualified and Awarded NET-JRF of both UGC and CSIR (1985) separately for Ph.D. Programme.

List of 10 major Publications: (in order of importance)

1. Nickel-mediated N‑arylation with arylboronic acids: An avenue to Chan-Lam coupling. Dushyant Singh Raghuvanshi, Amit Kumar Gupta, and Krishna Nand Singh, Organic Letters, 14 (17) (2012) 4326-4329.

2. MnO2 Promoted Sequential C�O and C�N Bond Formation via C�H Activation of Methylarenes: A New Approach to Amides. Rajeshwer Vanjari, Tirumaleswararao Guntreddi and Krishna Nand Singh, Organic Letters, 15 (18), (2013), 4908-4911.

3. Regioselective Hydrothiolation of Alkynes by Sulfonyl Hydrazides using Organic Ionic Base-Br�nsted Acid, Rahul Singh, Dushyant Singh Raghuvanshi and Krishna Nand Singh, Organic Letters, 15 (16), (2013), 4202-4205.

4. Convenient MW�assisted Synthesis of Unsymmetrical Sulfides Using Sulfonyl Hydrazides as Aryl Thiol Surrogate., Neetu Singh, Rahul Singh, D S Raghuvanshi and Krishna Nand Singh, Organic Letters, 15(22), (2013), 5874-5877.

5. Decarboxylative Thioamidation of Arylacetic and Cinnamic Acids: A New Approach to Thioamides. Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh, Organic Letters, 16 (14), (2014), 3624-3627.

6. AIBN-initiated metal free amidation of aldehydes using N-chloroamines. Rajeshwer Vanjari, Tirumaleswararao Guntreddi and Krishna Nand Singh, Green Chemistry, 16, (2014), 351-356.

7. Sulphur promoted C(sp3)-C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3, 4, 5-trisubstituted 1H-pyrazoles, Rajeshwer Vanjari, Tirumaleswararao G., Saurabh Kumar and Krishna Nand Singh, Chemical Communications, 51, (2015), 366-369.

8. Elemental Sulfur Mediated Decarboxylative Redox Cyclization Reaction of o-Chloronitroarenes and Arylacetic Acids. Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh, Organic Letters, (2015) http://dx.doi.org/10.1021/acs.orglett.5b00079..

9. An efficient TBAF-catalyzed three component synthesis of 3-indole derivatives under solvent-free conditions., Neetu Singh, Bharat Kumar Allam, D S Raghuvanshi and Krishna Nand Singh, Advanced Synthesis & Catalysis, 355 (2013), 1840-1848.

10. Nickel-Catalyzed C�S Bond Formation: Synthesis of Aryl Sulfides from Arylsulfonyl Hydrazides and Boronic Acids, Rahul Singh, Bharat Kumar Allam, Neetu Singh, Kumkum Kumari, Satish Kumar Singh and Krishna Nand Singh, Advanced Synthesis & Catalysis, (2015), DOI 10.1002/adsc.201400983.

Additional Information/ Achievements:

Life Member [LM 352], Chemical Research Society of India, Bangalore, India.

Life Member [F/5362 (LM) (1999)], Indian Chemical Society, Calcutta, India.

Life Member (LM No. 1020), Association of Chemistry Teachers, India.

Coordinator, BHU Alumni Cell, BHU (November 2011 to April 2013).

Organizing Secretary, International BHU Alumni Meet & Seminar on Mahamana�s Vision of Nation Building, 23 & 24 December 2012 (In commemoration of the 150th birth anniversary year of Mahamana Malviya).

List of Publications (Last Five Years):

1. Sulphur promoted C(sp3)-C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3, 4, 5-trisubstituted 1H-pyrazoles, Rajeshwer Vanjari, Tirumaleswararao G., Saurabh Kumar and Krishna Nand Singh, Chemical Communications, 51, (2015), 366-369.

2. Elemental Sulfur Mediated Decarboxylative Redox Cyclization Reaction of o-Chloronitroarenes and Arylacetic Acids. Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh, Organic Letters, (2015) http://dx.doi.org/10.1021/acs.orglett.5b00079.

3. Nickel-Catalyzed C�S Bond Formation: Synthesis of Aryl Sulfides from Arylsulfonyl Hydrazides and Boronic Acids, Rahul Singh, Bharat Kumar Allam, Neetu Singh, Kumkum Kumari, Satish Kumar Singh and Krishna Nand Singh, Advanced Synthesis & Catalysis, (2015), DOI 10.1002/adsc.201400983.

4. Copper catalysed C-N bond formation via sequential acylation and deacylation process: a novel strategy for the synthesis of benzanilides, Saurabh Kumar, Rajeshwer V., Tirumaleswararao G. and Krishna Nand Singh, RSC Advances, 5, (2015), 9920.

5. Decarboxylative Thioamidation of Arylacetic and Cinnamic Acids: A New Approach to Thioamides. Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh, Organic Letters, 16 (14), (2014), 3624-3627.

6. Convenient MW�assisted Synthesis of Unsymmetrical Sulfides Using Sulfonyl Hydrazides as Aryl Thiol Surrogate. Neetu Singh, Rahul Singh, D S Raghuvanshi and Krishna Nand Singh , Organic Letters, 15(22), (2013), 5874-5877.

7. Binuclear Cu(I) complex of (N'1E,N'2E)-N'1,N'2-bis(phenyl(pyridin-2-yl)methylene) oxalohydrazide: synthesis, crystal structure and catalytic activity for the synthesis of 1,2,3-triazoles, Divya Pratap Singh, Bharat Kumar Allam, Krishna Nand Singh and Vinod Prasad Singh, Journal of Molecular Catalysis A: Chemical, 398, (2015), 158-163.

8. Direct Conversion of Methylarenes into Dithiocarbamates, Thioamides and Benzyl Esters, Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh, Tetrahedron, 70, (2014), 3887-3892.

9.A simple and sustainable tetrabutylammonium fluoride (TBAF)�catalyzed synthesis of azaarene-substituted 3�hydroxy�2�oxindoles through sp3 C�H functionalization , Kumkum Kumari, Bharat Kumar Allam and Krishna Nand Singh, RSC Advances, 4 (38), (2014), 19789 - 19793.

10. AIBN-initiated metal free amidation of aldehydes using N-chloroamines., Rajeshwer Vanjari, Tirumaleswararao Guntreddi and Krishna Nand Singh, Green Chemistry, 16, (2014), 351-356.

11. Convenient MW�assisted Synthesis of Unsymmetrical Sulfides Using Sulfonyl Hydrazides as Aryl Thiol Surrogate. Neetu Singh, Rahul Singh, D S Raghuvanshi and Krishna Nand Singh, Organic Letters, 15(22), (2013), 5874-5877.

12. AIBN-initiated metal free amidation of aldehydes using N-chloroamines., Rajeshwer Vanjari, Tirumaleswararao Guntreddi and Krishna Nand Singh, Green Chemistry, 16, (2014), 351-356.

13. An efficient FeCl3 catalyzed condensation of thiols with 1,3-dicarbonyl compounds under solvent-free conditions. Kumkum Kumari and Krishna Nand Singh, SYNLETT, 25(2), (2014), 213-216.

14. Toxicological and Pharmacological Evaluation, Antioxidant, ADMET and Molecular Modeling of Selected Racemic Chromenotacrines {11-Amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the Potential Prevention and Treatment of Alzheimer's Disease, M. J. Oset-Gasque; M. P. Gonz�lez; J. P�rez-Pe�a; A. Romero; D. Hadjipavlou-Litina; E. Soriano; M. Chioua; A. Samadi; D. S. Raghuvanshi; K. N. Singh, J. Marco-Contelles, European Journal of Medicinal Chemistry, (2013), Accepted EJMECH-D-13-01634R1.

15. MnO2 Promoted Sequential C�O and C�N Bond Formation via C�H Activation of Methylarenes: A New Approach to Amides. Rajeshwer Vanjari, Tirumaleswararao Guntreddi and Krishna Nand Singh. Organic Letters, 15 (18), (2013), 4908-4911.

16. An efficient TBAF-catalyzed three component synthesis of 3-indole derivatives under solvent-free conditions. Neetu Singh, Bharat Kumar Allam, D S Raghuvanshi and Krishna Nand Singh Advanced Synthesis & Catalysis, 355 (2013), 1840-1848.

17. A binuclear Mn(II) complex as an efficient catalyst for transamidation of carboxamides with amines. Divya Pratap Singh, Bharat Kumar Allam, Krishna Nand Singh and Vinod P. Singh RSC Advances, 4 (2014) 1155-58.

18. Synthesis, characterization and catalytic application of some novel binuclear transition metal complexes of bis-(2-acetylthiophene) oxaloyldihydrazone for C-N bond formation. Divya Pratap Singh, Dushyant S. Raghuvanshi, K. N. Singh and Vinod P. Singh, Journal of Molecular Catalysis A: Chemical, 379 (2013) 21-29.

19. Regioselective Hydrothiolation of Alkynes by Sulfonyl Hydrazides using Organic Ionic Base-Br�nsted Acid. Rahul Singh, Dushyant Singh Raghuvanshi and Krishna Nand Singh, Organic Letters, 15 (16), (2013), 4202-4205.

20. An efficient and green synthesis of pyrazolphthalazinly spiro-oxindoles using task specific ionic liquid. Kumkum Kumari, Rahul Singh and Krishna Nand Singh, Indian J. Chem., (2014), Accepted.

21. Utilization of carbon disulfide as a powerful building block for the synthesis of 2-aminobenzoxazoles. Tirumaleswararao Guntreddi, Bharat Kumar Allam and Krishna Nand Singh RSC Advances, 3(25), (2013), 9875-9880.

22. An efficient L-proline catalyzed four-component synthesis of β-acetamido ketones and esters. Neetu Singh, Satish Kumar Singh and Krishna Nand Singh, Indian J. Chem., 52B, (2013), 915-921.

23. A novel and simple transamidation of carboxamides in 1,4-dioxane without a catalyst. Rajeshwer Vanjari, Bharat Kumar Allam and Krishna Nand Singh, Tetrahedron Letters, 54 (2013), 2553-2555.

24 Microwave assisted organic synthesis: Cross coupling and multicomponent reactions. Amit Kumar Gupta, Neetu Singh and Krishna Nand Singh, Current Organic Chemistry, 17(5), (2013), 474-490.

25. Hypervalent iodine catalyzed transamidation of carboxamides with amines. Rajeshwer Vanjari, Bharat Kumar Allam and Krishna Nand Singh, RSC Advances, 3 (2013), 1691-1694.

26. Cooperatively assisted N-arylation using organic ionic base�Br�nsted acid combination under controlled microwave heating. Rahul Singh, Bharat Kumar Allam, D S Raghuvanshi and Krishna Nand Singh Tetrahedron, 69 (2013), 1038-1042.

27. A novel and efficient synthesis of 2H-chromen-3-yl derivatives via CuI/(NH4)2HPO4 catalysed reaction of O-propargyl salicylaldehydes with active methylene compounds. Kumkum Kumari, D S Raghuvanshi and Krishna Nand Singh Tetrahedron, 69(1) (2013), 82-88.

28. An efficient synthesis of polyhydroquinolines using basic ionic liquid. D S Raghuvanshi and Krishna Nand Singh, Indian J. Chem., 52B (2013), 1218-1223.

29. Nickel-mediated N‑arylation with arylboronic acids: An avenue to Chan-Lam coupling. Dushyant Singh Raghuvanshi, Amit Kumar Gupta, and Krishna Nand SinghOrganic Letters, 14 (17) (2012) 4326-4329.

30. Simple and efficient one-pot synthesis of imidazo[1,2-a]pyridines catalyzed by magnetic nano-Fe3O4/KHSO4�SiO2. Tirumaleswararao Guntreddi, Bharat Kumar Allam and Krishna Nand Singh SYNLETT, 23(18) (2012), 2635-2638.

31. Iodine catalyzed highly efficient synthesis of 3-alkylated/alkenylated indoles. Neetu Singh and Krishna Nand Singh, SYNLETT, 23 (2012), 2116-2120.

32. An expeditious synthesis of tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-ones and dihydro-1,2,4-triazolo[1,5-a]pyrimidines. Kumkum Kumari, D S Raghuvanshi and Krishna Nand Singh, OPPI, 44 (2012), 460-466.

33. Microwave assisted eco-friendly protocol for one pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water. Kumkum Kumari, D S Raghuvanshi and Krishna Nand Singh Indian J. Chem., 51B (2012), 860-865.

34. NiCl2.6H2O as recyclable heterogeneous catalyst for N-arylation of amines and NH-heterocycles under microwave exposure. Amit Kumar Gupta, Tirumaleswara Rao G. and Krishna Nand Singh,Tetrahedron Letters, 53 (2012), 2218-2221.

35. Sc(OTf)3-catalyzed, solvent-free domino synthesis of functionalized pyrazoles under controlled microwave irradiation. Kumkum Kumari, D. S. Raghuvanshi, Viatcheslav Jouikov and Krishna Nand Singh Tetrahedron Letters, 53 (2012), 1130-1133.

36. An eco-safe approach to benzopyranopyrimidines and 4H-chromenes in ionic liquid at room temperature. A. K. Gupta, K. Kumari, N. Singh, D. S. Raghuvanshi and Krishna Nand Singh , Tetrahedron Letters, 53 (2012) 650-653.

37. Synthesis, characterization and catalytic property of ruthenium�terpyridyl complexes. Priti Sinha, D. S. Raghuvanshi, Krishna Nand Singh, Lallan Mishra Polyhedron, 31 (2012) 227-234.

38. DBU-catalyzed expeditious and facile multicomponent synthesis of N-arylquinolines under microwave. Satish Kumar Singh and Krishna Nand Singh Monatsh Chem, 143 (2012) 805-808.

39. A mild protocol for the synthesis of 2-arylbenzoxazoles from phenolic Schiff bases promoted by superoxide. Raghvendra Singh Raghuvanshi and Krishna Nand SinghIndian J. Chem., 51B (2012) 650-652.

40. An efficient and mild superoxide induced Michael addition of indoles to α,β-unsaturated ketones. Satish Kumar Singh and Krishna Nand Singh J. Indian Chem. Soc., 89 (2012) 401-404.

41. A highly efficient green synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives and their photophysical studies. D. S. Raghuvanshi and Krishna Nand SinghTetrahedron Letters, 52 (2011) 5702�5705.

42. Highly efficient one-pot synthesis of primary amides catalyzed by scandium (III) triflate under controlled MW. Bharat Kumar Allam and Krishna Nand SinghTetrahedron Letters, 52 (2011) 5851-5854.

43. Ionic liquid/potassium hydroxide catalyzed solvent-free, one-pot synthesis of diarylglycolic acids from aromatic aldehydes under microwave. Neetu Singh, Satish Kumar Singh, R. S. Khanna, Krishna Nand Singh Tetrahedron Letters, 52 (2011) 2419-2422.

44. An efficient phosphine-free Heck reaction using Pd[(L)Proline]2 complex ascatalyst in water under controlled MW. Bharat Kumar Allam and Krishna Nand Singh Synthesis, No. 7, (2011) 1125-1131.

45. Highly efficient cadmium-catalyzed three-component coupling of an aldehyde, alkyne, and amine via C�H Activation under microwave conditions. D. S. Raghuvanshi and Krishna Nand Singh, SYNLETT, No. 3, (2011) 0373�0377.

46. Eco-friendly and facile one-pot multicomponent synthesis of acridinediones in water under microwave. Satish Kumar Singh and Krishna Nand Singh, J. Heterocyclic Chem, 48 (2011) 69-73.

47. Microwave-assisted expeditious synthesis of novel benzo[b][1,8]-naphthyridine-3- carbonitriles. Satish Kumar Singh and Krishna Nand Singh J. Heterocyclic Chem, 48 (2011) 397-402.

48. Microwave-assisted one-pot synthesis of functionalized pyrimidines using ionic liquid. D. S. Raghuvanshi and K. N. Singh, J. Heterocyclic Chem, 48 (2011) 582-585.

49. A facile superoxide induced conversion of aromatic amines to azo compounds under microwave irradiation. S. Singh and Krishna Nand SinghJ. Indian Chem. Soc., 88 (2011) 841-843.

50. Superoxide ion promoted facile one-pot synthesis of O-alkyl-S-methyl dithiocarbonates from alcohol under mild reaction condition. Satish Kumar Singh and Krishna Nand Singh Phosphorus, Sulfur, and Silicon and the Related Elements, 186 (2011) 94-97.

51. An expeditious synthesis of novel pyranopyridine derivatives involving chromenes under controlled microwave irradiation. D. S. Raghuvanshi and Krishna Nand Singh ARKIVOC, 2010 (x) 305-317.

52. An efficient mono-mode MW controlled multicomponent synthesis of polysubstituted benzenes under solvent-free conditions. Krishna Nand Singh and Satish Kumar Singh, Indian J. Chem., 49B (2010) 826-829.

53. A facile multicomponent synthesis of tetrasubstituted imidazoles using Fe3+-K10 catalyst under solvent-free microwave conditions. D. S. Raghuvanshi and Krishna Nand Singh, Indian J. Chem., 49B (2010) 1394-1397.

54. An efficient protocol for multicomponent synthesis of spirooxindoles employing L-proline as catalyst at room temperature. D. S. Raghuvanshi and K. N. Singh, J. Heterocyclic Chem, 47 (2010) 1323-1327.

55. Glycine-catalyzed easy and efficient one-pot synthesis of polyhydroquinolines through Hantzsch multicomponent condensation under controlled microwave. Satish Kumar Singh and Krishna Nand Singh J. Heterocyclic Chem, 47 (2010) 194-198.

56. Microwave-assisted synthesis of some potent Mannich bases, Schiff bases, thiazolidinones and thiohydantoin derivatives of isatins. Dushyant Singh Raghuvanshi and Krishna Nand Singh Phosphorus, Sulfur, and Silicon and the Related Elements 185(11) (2010) 2243-2248.