The primary objective of my research is to study the cytotoxic effects of some of the chemotherapeutic agent of plant origin as well as novel synthetic complexes in controlling tumor growth. Efforts are also being made to link the indigenous knowledge of medicinal plant to modern research activity to provide a new approach for effective drug discovery. Studies are also focused on expression of microRNAs in hypoxia condition during tumorigenesis so as to develop prognostic markers for cancer diagnosis as well as efficient targets for cancer therapy

Ten best Publications:

1. Paul A, Sellamuthuv A, Sharma G, Kuznetsov ML, Koch B, Guedes da Silva MFC, Pombeiro AJL (2015) Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(II) complexes. Dalton Transactions 44:19983-96 (IF 4.2)
2. Singh RP, Sharma G, Sonali, Singh S, Kumar M, Pandey BL. Koch B, Muthu MS (2016) Vitamin E TPGS conjugated carbon nanotubes improved efficacy of docetaxel with safety for lung cancer treatment. Colloids and surfaces B: Biointerfaces. 141: 429-442 (IF 4.15)
3. M Rai, SK Singh, AK Singh, R Prasad, Koch B, Mishra K, and Rai SB (2015) Enhanced red upconversion emission, magnetoluminescent behavior, and bio-imaging application of NaSc0.75Er0.02Yb0.18Gd0.05F4@AuNPs nanoparticles. ACS Appl. Mater. Interfaces 7(28):15339-50 (IF 6.8)
4. Singh RS, Gupta RK, Paitandi R. P, Dubey M, Sharma G, Koch B. and Pandey DS (2015) Morphological tuning via structural modulations in AIE luminogens with least possible variables and their use in live cell imaging. ChemComm 51(44):9125-9128. (IF 6.718)
5. Gupta RK, Sharma G, Pandey R, Kumar A, Koch B, Li PZ, Xu Q, Pandey DS (2013) DNA/Protein Binding, Molecular Docking, and in Vitro Anticancer Activity of Some Thioether-Dipyrrinato Complexes. Inorg Chem. 52: 13984-13996 (IF 4.794)
6. Paitandi RP, Gupta RK, Singh R, Sharma G, Koch B, Pandey DS (2014) Interactions of ferrocene-appended Ru(II), Rh(III) and Ir(III) dipyrrinato complexes with DNA/protein, molecular docking and antitumor activity Eur. J. Med Chem., 84, 17-29. (IF 3.432)
7. Koch B, Basu Baul TS, Chatterjee A (2008) Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin (IV) compounds. J Applied Toxicol. 28: 430-438. (IF 3.174)
8. Koch B, Basu Baul TS, Chatterjee A (2009) p53-dependent antiproliferative and antitumor effect of novel alkyl series of Diorganotin (IV) compounds. Invest New Drugs. 27: 319-326. (IF 2.927)
9. Adhikary J, Chakraborty P, Chattopadhyay T, Prasad R, Motro Y, Koch B, Mautner F.A, Miller Y, Das D. (2015) Configuration change from cis to trans of isothiocyanato groups in nickel(II) species: Experimental verification and theoretical interpretation of reaction consequence and study on their bio-activity, Polyhedron 93: 55-65 (IF 2.05)
10. Prasad R and Koch B (2014) Antitumor Activity of Ethanolic Extract of Dendrobium formosum in T-Cell Lymphoma: An In Vitro and In Vivo Study, BioMed Res Int, Article ID 753451, 11 pages doi:10.1155/2014/753451. (IF 1.55)

Full List of Publications:

1. Hazra S, Paul A, Sharma G, Koch B, Silva MFCG da, Pombeiro AJL (2016) Sulfonated Schiff Base Sn (IV) complexes as potential anticancer agents Journal of Inorganic Biochemistry doi:10.1016/j.jinorgbio.2016.06.008 (IF 3.44)
2. Singh RP, Sharma G, Kumari L, Koch B, Singh S, Bharti S, Rajinikanth PS, Pandey BL, Muthu MS (2016) RGD-TPGS decorated theranostic liposomes for brain targeted delivery Colloids and Surfaces B: Biointerfaces 147, 129-141 (IF 4.15)
3. Singh DP, Dwivedi R, Singh AK, Koch B, Singh P, Singh VP (2016) A dihydrazone based �turn�on� fluorescent probe for selective determination of Al 3+ ions in aqueous ethanol Sensors and Actuators B: Chemical 238, 128-137 (IF 4.7)
4. RP Singh, G Sharma, S Singh, SCU Patne, BL Pandey, B Koch, Muthu MS (2016) Effects of transferrin conjugated multi-walled carbon nanotubes in lung cancer delivery Materials Science and Engineering: C. 67, 313-325 (IF 3.42)
5. Diwan U, Kumar V, Mishra RK, Rana NK, Koch B, Singh MK, Upadhyay KK (2016) A Pyrene-benzthiazolium conjugate portraying aggregation induced emission, a ratiometric detection and live cell visualization of HSO3- . Analytica Chimica Acta, 10.1016/j.aca.2016.04.057 (IF 4.513)
6. Razi SS, Ali R, Gupta RC, Dwivedi SK, Sharma G, Koch B, Misra A (2016) Phenyl-end-capped-thiophene (P-T type) based ICT fluorescent probe (D�p�A) for detection of Hg2+ and Cu2+ ions: Live cell imaging and logic operation at molecular level. Journal of Photochemistry and Photobiology A Chemistry. DOI:10.1016/j.jphotochem.2016.03.015 (IF 2.459)
7. Singh RP, Sharma G, Sonali, Singh S, Kumar M, Pandey B. L. Koch B, Muthu MS, (2016) Vitamin E TPGS conjugated carbon nanotubes improved efficacy of docetaxel with safety for lung cancer treatment. Colloids and surfaces B: Biointerfaces. 141: 429�442 (IF 4.15)
8. Paitandi RP, Singh RS, Mukhopadhyay S, Sharma G, Koch B , Vishnoi P, Pandey DS (2016) Synthesis, characterization, DNA binding and cytotoxicity of fluoro-dipyrrin based arene ruthenium (II) complexes. Inorganica Chimica Acta doi:10.1016/j.ica.2016.03.003 (IF 2.05)
9. Prasad S, Koch B and Chaube SK (2016) Maturation promoting factor destabilization facilitates postovulatory aging-mediated abortive spontaneous egg activation in rat. Development Growth and Differentiation, DOI: 10.1111/dgd.12272 (IF 2.42)
10. Sonali S, Singh RP, Singh N, Sharma G, Vijayakumar MR, Koch B, Singh S, Singh U, Dash D, Pandey BL, Muthu MS (2016). Transferrin liposomes of docetaxel for brain targeted cancer applications: formulation and brain theranostics. Drug Delivery. 10:1-37, (IF 4.84)
11. Prasad S, Koch B,. Chaube SK (2016) Involvement of Cyclin Dependent Kinase 1 during Postovulatory Aging-Mediated Abortive Spontaneous Egg Activation in Rat Eggs Cultured In Vitro. Cellular reprogramming 18(2) (IF 1.79)
12. Prasad S, Koch B, Chaube SK (2016) RO-3306 prevents postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro. Biomedicine & Pharmacotherapy 78: 216�225 (IF 2.02)
13. Singh RP, Sharma G ,Sonali, Agrawal P, Pandey BL, Koch B, Muthu MS (2015) Transferrin receptor targeted PLA-TPGS micelles improved efficacy and safety in docetaxel delivery Int. Journal of Biological Macromolecules. 83:335-44 (IF 2.86)
14. Paul A, Sellamuthuv A, Sharma G, Kuznetsov ML, Koch B, Guedes da Silva MFC, Pombeiro AJL (2015) Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(II) complexes. Dalton Transactions. 44(46):19983-96 (IF 4.2)
15. Mukhopadhyay S, Gupta RK, Paitandi RP, Rana NK, Sharma G, Koch B, Rana LK, Hundal MS, and Pandey DS (2015) Synthesis, Structure, DNA/Protein Binding, and Anticancer Activity of Some Half-Sandwich Cyclometalated Rh(III) and Ir(III) Complexes. Organometallics. 34, 4491-4506 (IF 4.2)
16. Paul A, Anbu S, Sharma G, Kuznetsov ML, Guedes da Silva MFC, Koch B and Pombeiro AJL (2015) Intracellular detection of Cu2+ and S2- ions through a quinazoline functionalized benzimidazole-based new fluorogenic differential chemosensor. Dalton Transactions. 44(38):16953-64 (IF 4.2)
17. Rai M, Singh SK, Singh AK, Prasad R, Koch B, Mishra K, and Rai SB (2015) Enhanced red upconversion emission, magnetoluminescent behavior, and bio-imaging application of NaSc0.75Er0.02Yb0.18Gd0.05F4@AuNPs nanoparticles. ACS Appl. Mater. Interfaces. 7(28):15339-50 (IF 6.8)
18. Prasad S, Tiwari M, Koch B, Chaube SK,(2015) Morphological, cellular and molecular changes during postovulatory egg aging in mammals" J. Biomed. Sci. 22(1):36. (IF 2.7)
19. Singh RS, Gupta RK, Paitandi R. P, Dubey M, Sharma G, Koch B. and Pandey DS (2015) Morphological tuning via structural modulations in AIE luminogens with least possible variables and their use in live cell imaging. ChemComm 51(44):9125-9128. (IF 6.718)
20. Adhikary J, Chakraborty P, Chattopadhyay T, Prasad R, Motro Y, Koch B, Mautner F.A, Miller Y, Das D. (2015) Configuration change from cis to trans of isothiocyanato groups in nickel(II) species: Experimental verification and theoretical interpretation of reaction consequence and study on their bio-activity, Polyhedron 93: 55�65 (IF 2.05)
21. Paul A, Gupta RK, Dubey M, Sharma G, Koch B, Hundal G, Hundal MS and Pandey DS (2014) Potential apoptosis inducing agents based on a new benzimidazole schiff base ligand and its dicopper(II) complex. RSC Advances, 4, 41228. (IF 3.708)
22. Roy M, Tapadia MG, Joshi S, Koch B (2014) Molecular and genetic basis of depression. Journal of Genetics ; 93: 879-92. (IF1.01)
23. Paitandi RP, Gupta RK, Singh R, Sharma G, Koch B, Pandey DS, (2014) Interactions of ferrocene-appended Ru(II), Rh(III) and Ir(III) dipyrrinato complexes with DNA/protein, molecular docking and antitumor activity Eur. J. Med Chem., 84, 17-29 (IF 3.432)
24. Prasad R and Koch B (2014) Antitumor Activity of Ethanolic Extract of Dendrobium formosum in T-Cell Lymphoma: An In Vitro and In Vivo Study, BioMed Res Int, Article ID 753451. (IF 1.55)
25. Gupta RK, Sharma G, Pandey R, Kumar A, Koch B, Li PZ, Xu Q, Pandey DS (2013) DNA/Protein Binding, Molecular Docking, and in Vitro Anticancer Activity of Some Thioether-Dipyrrinato Complexes. Inorg Chem. 52: 13984-13996 (IF 4.794)
26. Gupta G , Sharma G, Koch B, Park S, Lee SS, Kim J (2013) Syntheses, characterization and molecular structures of novel Ru(II), Rh(III) and Ir(III) complexes and their possible roles as antitumour and cytotoxic agents. New J. Chem. 37: 2573-2581 (IF 3.159)
27. Gupta RK, Pandey R, Sharma G, Prasad R, Koch B, Srikrishna S, Li PZ, Xu Q, Pandey DS (2013) DNA Binding and Anti-Cancer Activity of Redox-Active Heteroleptic Piano-Stool Ru(II), Rh(III), and Ir(III) Complexes Containing 4-(2-Methoxypyridyl)phenyldipyrromethene. Inorg Chem. 52: 3687-3698. (IF 4.794)
28. Koch B, Basu Baul T S, Chatterjee A (2008) Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin (IV) compounds. J Applied Toxicol. 28: 430-438.
29. Koch B, Basu Baul T S, Chatterjee A (2009) p53-dependent antiproliferative and antitumor effect of novel alkyl series of Diorganotin (IV) compounds. Invest New Drugs. 27: 319-326.