Mrs. Bhagyalaxmi Mohapatra |
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Assistant Professor
Ph.D. (BHU)
Contact Information: +91 542 2369905 (office); +91 542 2570280 (home)
Email Id: [email protected]; [email protected] Fax:+91 542 2368457
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Academic Qualifications: |
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S. No. | Degree | Institution | Year |
1. | B.Sc. | Utkal University | 1982 |
2. | M.Sc. | Utkal University | 1984 |
3. | Ph. D. | Banaras Hindu University | 1994 | |
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Area of specialization/awards/achievements: |
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Human molecular Genetics, Developmental Genetics, Cytogenetics, spermatogenesis. My research interest is cardiovascular genetics, particularly genetic analysis of congenital heart disease (CHD) and cardiomyopathy. Goal of my laboratory is to identify, map, and characterize the genes responsible for familial cadiomyopathies and congenital heart diseases as well as to determine the prevalence of genetic mutations that cause these disorders in Indian population..
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Current Project Undertaken as PI/ Co PI: |
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S. No. | Name of the Project | Duration | Source of Funding | Amount of Funding (Rs) | Any other Information |
1. | Role of Muscle LIM Protein (MLP) in Dilated Cardiacmyopathy(P.I) | 2013-2016 | BRNS, Mumbai | Rs. 32.5 Lacs | |
2. | Genetics of Dilated Cardiomyopathy (P.I) | 2016-2019 | DBT | Rs. 122.27 Lacs | |
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Any additional information:
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Post-doctoral Res. Associate from Sept 2000-June 2009; in Department of Pediatrics- Cardiology, Baylor College of Medicine/ Texas Childrens Hospital, Houston, Texas, USA.
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Post-doctoral fellowship, June 1999 - Aug 2000 (NIH Grant, HD- 16843) in Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX , USA.
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Post-doctoral fellowship, Nov. 1995- July 1998 (Mellon & Conrad foundation) in Genes & Protein Laboratory, National Institute of
Immunology, New Delhi, India.
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Awarded Senior research Fellowship from Council for Scientific and Industrial Research (CSIR), Govt. of India (1990-1992)
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Junior Research Fellowship from University Grants Commission (UGC), Govt. of India (1987-1990)
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Awarded National Merit Scholarship, Dept.of Education, Govt. of INDIA (1977-1982)
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Treasurer, Symposium on DNA Repair, Genomic Instability and Cancer, March 4-5, 2010, Dept of Zoology, BHU
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Member of Organizing committee , Symnposium on Population Genetics and Chromatin Dynamics, January 23nd-23rd, 2012, Dept of Zoology, BHU
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Member of Organizing committee, International Symposium on developmental and complex Disorders and 38th Annual conference of Indian Society of Human Genetics: Genomics and Community Health, December 9-11, 2012, Dept of Zoology, BHU
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Member of Organizing committee , International symposium on Karyotype to Haplotype and beyond, December 8-10, 2013, Dept of Zoology, BHU
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Life member of Indian Society of Human Genetics (ISHG)
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Life member of Indian Society of Cell Biology (ISCB)
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List of 10 major Publications:
- Bhagyalaxmi Mohapatra, Brett Casey, Hua Li, Trang Ho, Liana smith, Susan Frenbach, Laura Molinary, Stephen R Niesh, John Lynn Jefferies, Willium J Craigen, Jeffery A. Towbin, Stephanie M. Were and John W. Belmont Identification and functional charecterization of Nodal rare Variants in heterotaxy and isolated cardiovascular malformations. Human Molecular Genetics, 2009 , Vol18 (5) 861-71
Impact Factor: 7.69 5 Yrs. Impact factor: 7.54 Citation : 80
- Bhagyalaxmi Mohapatra, G. Wesley Vick III, Charles D. Fraser, Sarah K. Clunie, Jeffrey A. Towbin, Gianfranco Sinagra and Matteo Vatta (2010) : Short-term LVAD Therapy Improve Gene Expression in failing Heart and Elicits Pro-Apoptotic Cytokines Inhibition Associated with Heat Shock Transcription Factor-1 Upregulation. Journal of Heart and Lung Transplantation, 2010, VOL 29 pages 98-104
Impact Factor: 5.1 5 Yrs. Impact factor: 3.63 Citation: 21
- Qian Li, Mohapatra B, Akasaka T, Liu J, Occor K, Towbin JA ad Bodmer R: (2008): Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with possible implications for human heart disease. Proceedings of the National Academy of Sciences, USA , Dec 16, 2008, Vol 105 (50) p 19833-19838.
Impact Factor: 9.74 5 Yrs. Impact factor: 10.58 Citation: 53
- Matteo Vatta*, Bhagyalaxmi Mohapatra*, Shinawe Jimenez, Ximena Sanchez, Georgine Faulkner, Zeev Perles, Gianfranco Sinagra, Jiuann-Huey Lin, Thuy M. Vu, Qiang Zhou, Karla R. Bowles, Andrea Di Lenarda, Lisa Schimmenti, Michelle Fox, Michelle A. Chrisco, Ross T. Murphy, William McKenna, Perry Elliott, Neil E. Bowles, Ju Chen, Giorgio Valle, and Jeffrey A. Towbin. Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. Journal of the American College of Cardiology, 2003 Dec 3; 42 (11): 2014-27
* Equal contributor first author
Impact Factor: 14.086 5 Yrs. Impact factor: 13.7 Citation : 445
- Bhagyalaxmi Mohapatra, Shinawe Jimenez, Jiuann Huey Lin, Karla R. Bowles, Karen J. Coveler, Joseph G. Marx, Michele A. Chrisco, Ross T. Murphy, Paul R. Lurie, Robert J. Schwartz, Perry M. Elliott, Matteo Vatta, William McKenna, Jeffrey A. Towbin, and Neil E. Bowles. Mutations in the Muscle LIM Protein and Alpha-Actinin 2 Genes in Dilated Cardiomyopathy and Endocardial Fibroelastosis. Mol Genet Metab, 2003; 80:207-215
Impact Factor: 2.84 5 Yrs. Impact factor: 2.94 Citation : 195
- Li Qian, Joshua D. Wythe, Jiandong Liu, Jerome Cartry, Georg Vogler, Bhagyalaxmi Mohapatra, Robyn T Otway Y, Yu Huang, Isabelle N. King, Marjorie Maillet, Yi Zheng, Tomothy Crawley, Ouarda Taghli-Lamallem, Christopher semsarian, Sally Dunwoodie, David Winlaw, Richard P. Harvey, Diane Fatkin, Jeffrey A. Towbin, Jeffery Molkentin, Deepak Srivastava, Karen Occore, Benoit G. Bruneau, Rolf Bodmer. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. Journal of Cell Biol. June 2011 Vol. 193 (7) 1181-1196
Impact Factor: 10.82 5 Yrs. Impact factor: 10.37 Citation: 42
- Marco Ricci*, Bhagyalaxmi Mohapatra*, Arnel Urbiztondo, Rhea J. Birusingh, Micaela Morgado, Maria M. Rodriguez, Joy Lincoln, Matteo Vatta. Differential Changes in TGF-beta/BMP Signaling Pathway in the Right Ventricular Myocardium of Newborns With Hypoplastic Left Heart Syndrome. Journal of Cardiac Failure, 2010 May VOL16 (8) 628-634
* Equal contributor first author
Impact Factor: 3.44 5 Yrs. Impact factor: 3.4 Citation: 15
- Barbara Janssens, Bhagyalaxmi Mohapatra, Matteo Vatta, Steven Goossens, Griet Vanpoucke, Patrick Kools, Tony Montoye, Jolanda van Hengel, Neil E. Bowles, Frans van Roy, Jeffrey A. Towbin. Assessment of the CTNNA3 gene encoding human T-catenin regarding its involvement in dilated cardiomyopathy. Hum Genet, 2003 Mar; 112(3):227-36.
Impact Factor: 4.63 5 Yrs. Impact factor: 4.49 Citation : 30
- Marvin L. Meistrich, Bhagyalaxmi Mohapatra, Cynthia R. Shirley and Ming Zhao (2003): Roles of trasition nuclear proteins In spermiogenesis. Chromosoma Focus. 2003 Feb; 111:483-488
Impact Factor: 4.97 5 Yrs. Impact factor: 4.34 Citation: 229
- Mohapatra B, Verma S, Srinivasan S and Suri A (1998): Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. Biochemical & Biophysical research Communications. 244, 540-545
Impact Factor: 2.5 5 Yrs. Impact factor: 2.7 Citation: 21
Full list of Publications:
- Ritu Bhardwaj, Sunil Kumar Rai, Abhishek Kumar Yada1, Siddharth Lakhotia, Damyanti Agrawal, Ashok Kumar, Bhagyalaxmi Mohapatra. Epidemiology of congenital heart disease in India. Congenital Heart Disease, Willey, 8 Sep 2015 vol.10(5) 437-46
Impact Factor: 1.1 5 Yrs. Impact factor: 1.24 Citation:4
- Ritu Bhardwaj, Damyanti Agrawal, Ashok Kumar, Bhagyalaxmi Mohapatra. Identification of muttions in bone morphogenetic protein 2, 4,7 in congenital heart disease patients from Indian population. Molecular Cytogenetics Jan 2014 vol.7 p32
Impact Factor: 2.14 5 Yrs. Impact factor: 2.05
- Li Qian, Joshua D. Wythe, Jiandong Liu, Jerome Cartry, Georg Vogler, Bhagyalaxmi Mohapatra, Robyn T Otway Y, Yu Huang, Isabelle N. King, Marjorie Maillet, Yi Zheng, Tomothy Crawley, Ouarda Taghli-Lamallem, Christopher semsarian, Sally Dunwoodie, David Winlaw, Richard P. Harvey, Diane Fatkin, Jeffrey A. Towbin, Jeffery Molkentin, Deepak Srivastava, Karen Occore, Benoit G. Bruneau, Rolf Bodmer. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. Journal of Cell Biol. June 2011 Vol. 193 (7) 1181-1196
Impact Factor: 9.9 5 Yrs. Impact factor: 10.12 API: 25
- Marco Ricci*, Bhagyalaxmi Mohapatra*, Arnel Urbiztondo, Rhea J. Birusingh, Micaela Morgado, Maria M. Rodriguez, Joy Lincoln, Matteo Vatta. Differential Changes in TGF-β/BMP Signaling Pathway in the Right Ventricular Myocardium of Newborns With Hypoplastic Left Heart Syndrome. Journal of Cardiac Failure, 2010 May VOL16 (8) 628-634
* Equal contributor first author
Impact Factor: 3.5 5 Yrs. Impact factor: 3.5 API: 18
Citation Index:
- Bhagyalaxmi Mohapatra, G. Wesley Vick III, Charles D. Fraser, Sarah K. Clunie, Jeffrey A. Towbin, Gianfranco Sinagra and Matteo Vatta (2010) : Short-term LVAD Therapy Improve Gene Expression in failing Heart and Elicits Pro-Apoptotic Cytokines Inhibition Associated with Heat Shock Transcription Factor-1 Upregulation. Journal of Heart and Lung Transplantation, 2010, VOL 29 pages 98-104
Impact Factor: 3.5 5 Yrs. Impact factor: 2.9 API: 24
Citation Index: 1 (Ref: ISI Web of SCIENCE Citation Index)
- Bhagyalaxmi Mohapatra, Brett Casey, Hua Li, Trang Ho, Liana smith, Susan Frenbach, Laura Molinary, Stephen R Niesh, John Lynn Jefferies, Willium J Craigen,Jeffery A. Towbin, Stephanie M. Were and John W. Belmont Identification and functional charecterization of Nodal rare Variants in heterotaxy and isolated cardiovascular malformations. Human Molecular Genetics, 2009 , Vol18 (5) 861-71
Impact Factor: 7.3 5 Yrs. Impact factor: 7.7 API: 30
Citation Index: 11 (Ref: ISI Web of SCIENCE Citation Index)
- Qian Li, Mohapatra B, Akasaka T, Liu J, Occor K, Towbin JA ad Bodmer R: (2008): Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with possible implications for human heart disease. Proceedings of the National Academy of Sciences, USA , Dec 16, 2008, Vol 105 no. 50 pages 19833-19838.
Impact Factor: 9.4 5 Yrs. Impact factor: 10.3 API: 25
Citation Index: 4 (Ref: ISI Web of SCIENCE Citation Index)
- Wu G, Ai T, Kim J J, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Qi M, Moss A J, Shimizu W, Towbin JA, Cheng J and Vatta M. Alpha-1-Syntrophin mutation and the Long-QT syndrome. Circulation : Arrhythmia and Electrophysiology. 2008; 1:193-201
Impact Factor: 3.4 5 Yrs. Impact factor: 3.4 API: 21
Citation Index: 13 (Ref: ISI Web of SCIENCE Citation Index)
- Brandon N. Anim, Bhagyalaxmi Mohapatra, Matteo Vatta, Debra Murray, George Weinstock and Richard Gibbs: Role of the beta-adrenergic receptors in the cardiac response to beta-blocker therapy. The FASEB Journal, 2008; 22: 1046
Impact Factor: 6.4 5 Yrs. Impact factor: 7.1 API: 25
- Jagdish N, Rana R, Selvi R, Mishra D, Shankar S, Mohapatra B, Suri A : Molecular cloning and characterization of macaque sperm associated antigen 9 (SPAG9): An othologue of human SPAG9 gene. Mol Reprod Dev, 2005 May. 71 (1): p 58-66
Impact Factor: 2.0 5 Yrs. Impact factor: 2.1 API: 21
Citation Index: 4 (Ref: ISI Web of SCIENCE Citation Index)
- S. Shankar, B. Mohapatra, S. Verma, R. Selvi, N. Jagadish, A. Suri : Isolation and characterization of a haploid germ cell specific sperm associated antigen 9 (SPAG9) from the baboon. Mol Reprod Dev, 2004 Oct.69(2): p 186).
Impact Factor: 2.0 5 Yrs. Impact factor: 2.1 API: 21
Citation Index: 17 (Ref: ISI Web of SCIENCE Citation Index)
- Matteo Vatta, Bhagyalaxmi Mohapatra, Shinawe Jimenez, Ximena Sanchez, Neil E. Bowles, Karla R. Bowles, and Jeffrey A. Towbin: Do Cypher Gene Mutations cause Left Ventricular Noncompaction With sub clinical Myopathy? Journal of the American College of Cardiology, 2004 Sep. 44 (5) p1139-1145 Letters to the Editor - Reply
Impact Factor: 12.5 5 Yrs. Impact factor: 11.5 API: 25
- Matteo Vatta, Bhagyalaxmi Mohapatra, Shinawe Jimenez, Ximena Sanchez, Neil E. Bowles, Karla R. Bowles, and Jeffrey A. Towbin: Do Cypher Gene Mutations cause Left Ventricular Noncompaction With sub clinical Myopathy? Journal of the American College of Cardiology, 2004 Sep. 44 (5) p1139-1140
Impact Factor: 12.5 5 Yrs. Impact factor: 11.5 API: 25
- Saguna Verma; Bhagyalaxmi Mohapatra; Nirmala Jagadish; Ramasamy Selvi; Pragyan Roy; Ritu Rana; Kavitha Lakshmi; Anil Suri: Molecular Cloning, Expression of Testicular Transcript Abundant in Germ Cells and Immunobiological Effects of the Recombinant Protein. Amrican J. of Reproductive Immunology ,2004 Aug; 52 pp. 164-173.
Impact Factor: 2.1 5 Yrs. Impact factor: 1.95 API: 21
Citation Index: 2 (Ref: ISI Web of SCIENCE Citation Index)
- Belmont JW, Mohapatra B, Towbin JA, Ware SM.: Molecular genetics of heterotaxy syndromes. Curr Opin Cardiol.2004 May 19(3):216-20
Impact Factor: 2.66 5 Yrs. Impact factor: 2.66 API: 21
Citation Index: 29
- Ming Zhao, Cynthia R Shirley, Sharato Hayashi, Ludovic Marcon, Bhagyalaxmi Mohapatra, Ryota suganuma, Richard R Behringer, Guylain Boissonneault, Ryuzo Yanagimachi, Marvin L. Meistrich: Trasition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis, 2004; 38: 200-213
Impact Factor: 2.2 5 Yrs. Impact factor: 2.6 API: 21
Citation Index: 63 (Ref: ISI Web of SCIENCE Citation Index)
- Matteo Vatta*, Bhagyalaxmi Mohapatra*, Shinawe Jimenez, Ximena Sanchez, Georgine Faulkner, Zeev Perles, Gianfranco Sinagra, Jiuann-Huey Lin, Thuy M. Vu, Qiang Zhou, Karla R. Bowles, Andrea Di Lenarda, Lisa Schimmenti, Michelle Fox, Michelle A. Chrisco, Ross T. Murphy, William McKenna, Perry Elliott, Neil E. Bowles, Ju Chen, Giorgio Valle, and Jeffrey A. Towbin. Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. Journal of the American College of Cardiology, 2003 Dec 3; 42 (11): 2014-27
* Equal contributor first author
Impact Factor: 12.5 5 Yrs. Impact factor: 11.5 API: 30
Citation Index: 213 (Ref: ISI Web of SCIENCE Citation Index)
- Bhagyalaxmi Mohapatra, Shinawe Jimenez, Jiuann Huey Lin, Karla R.
Bowles, Karen J. Coveler, Joseph G. Marx, Michele A. Chrisco, Ross T. Murphy, Paul R. Lurie, Robert J. Schwartz, Perry M. Elliott, Matteo Vatta, William McKenna, Jeffrey A. Towbin, and Neil E. Bowles. Mutations in the Muscle LIM Protein and Alpha-Actinin 2 Genes in Dilated Cardiomyopathy and Endocardial Fibroelastosis. Mol Genet Metab, 2003;80:207-215
Impact Factor: 2.89 5 Yrs. Impact factor: 2.68 API: 24
Citation Index: 97 (Ref: ISI Web of SCIENCE Citation Index)
- Barbara Janssens, Bhagyalaxmi Mohapatra, Matteo Vatta, Steven Goossens, Griet Vanpoucke, Patrick Kools, Tony Montoye, Jolanda van Hengel, Neil E. Bowles, Frans van Roy, Jeffrey A. Towbin. Assessment of the CTNNA3 gene encoding human T-catenin regarding its involvement in dilated cardiomyopathy. Hum Genet, 2003 Mar; 112(3):227-36.
Impact Factor: 4.5 5 Yrs. Impact factor: 3.9 API: 21
Citation Index: 18 (Ref: ISI Web of SCIENCE Citation Index)
- Marvin L. Meistrich, Bhagyalaxmi Mohapatra, Cynthia R. Shirley and Ming Zhao (2003): Roles of trasition nuclear proteins In spermiogenesis.Chromosoma Focus. 2003 Feb; 111:483-488
Impact Factor: 4.97 5 Yrs. Impact factor: 4.34 API: 21
Citation Index: 104 (Ref: ISI Web of SCIENCE Citation Index)
- Ming Zhao, Cynthia R Shirley, Y Eugene. Yu, Bhagyalaxmi Mohapatra, Yun Zhang, Emmanual Unni, Jian M. Deng, Nelson A. Arango, Michael M Weil, Lonnie D. Russell, Richard R Behringer, and Marvin L. Meistrich (2001): Targeted disruption of Trasition protein 2 gene affects sperm chromatin structure and reduces fertility spermatogenesis In mice. Molecular and Cellular Biology 21, 7243-7255
Impact Factor: 6.0 5 Yrs. Impact factor: 6.36 API: 25
Citation Index: 88 (Ref: ISI Web of SCIENCE Citation Index)
- Mohapatra B, Verma S, Srinivasan S and Suri A (1998): Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. Biochemical & Biophysical research Communications. 244, 540-545
Impact Factor: 2.5 5 Yrs. Impact factor: 2.7 API: 24
Citation Index: 9 (Ref: ISI Web of SCIENCE Citation Index)
- Srinivas S, Mohapatra B and Suri A (1998): Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. Biochemical & Biophysical Research Communications. 243, 561-565
Impact Factor: 2.5 5 Yrs. Impact factor: 2.7 API: 21
Citation Index: 30 (Ref: ISI Web of SCIENCE Citation Index)
- Chatterjee A, Jacob-Raman M and Mohapatra B (1989): potentiation of Blemycin-induced chromosome aberration by the radiprotector reuced glutathione.
Mutation Res. 214, 207-213
Impact Factor: 3.55 5 Yrs. Impact factor: 3.76 API: 21
Citation Index: 21 (Ref: ISI Web of SCIENCE Citation Index)
Conference Proceedings/Abstracts published in Journals:
- Ritu Bhardwaj, Ashok Kumar, Damayanti Agrawal, Bhagyalaxmi Mohapatra; Congenital Heart Disease in India. Cadiology (online e-ISSN 1421-9751)
- Yutao Xi, Tomohiko Ai, Bhagyalaxmi Mohapatra, Geru Wu, Haider S. Alwash, Junping Sun, Ross T Murphy, Shaughan, Dickie, William McKenna, Jeffrey A Towbin, Jie Cheng, Matteo Vatta. Abstract 12290: The African-American Single Nucleotide Polymorphism (snp) Rs34423165 in Ldb3 Alters Kv7.1 in Familial DCM with Qt-Prolongation. Circulation, 2011;124(21):A12290.
- Matteo Vatta; Tomohiko Ai; Geru Wu; Jeffrey J Kim; Bhagyalaxmi Mohapatra; Yutao Xi; Michael J Ackerman; Sharhzad Abbasi; Zhaohui Li; Jie Cheng; Jeffrey A Towbin. A Novel Variant of Alpha-1-Syntrophin May Cause Long-QT Syndrome. Circulation. (Genetics of Cardiac Conduction: QT Intervals and Arrhythmias) 2007;116: II_653
- Lin JHL, Sanchez X, Mohapatra B, Jimenez S, Bowles KR, Marx JG, Murphy RT, Li H, Schwartz RJ, Elliot PM, McKenna W, Vatta M, Towbin JA, Bowles NE. Mutations in the muscle LIM protein (MLP) gene in dilated cardiomyopathy. Pediatric Research 55 (4): 49A-49A 276 Part 2 Suppl. S, APR 2004
- JHI Lin, X Sanchez, B Mohapatra, S Jimenez, RJ Schwartz, JA Towbin
Functional analysis of mutations in the muscle LIM protein (MLP) gene in dilated cardiomyopathy. Circulation, 2004; 110 (17), 228-228
- Bowles NE, Mohapatra B, Jimenez S, Lin JH, Marx JG, Li H, Lurie P, Schwartz RJ, Vatta M, Towbin JA, Bowles KR. Mutations in the Muscle LIM Protein Gene in dilated Cardiomyoapthy and Endocardial Fibroelastosis. Pediatric Research, 2003 53 (4): 188 Part 2 Suppl. S APR
- Sanchez X, Mohapatra B, Jimenez S, Lin JH, Faulkner G, Vu TM, Zhou Q, Bowles KR, Schimmenti L, Murphy RT, McKenna WJ, Bowles NE, Chen J, Towbin JA, and Vatta M. Role of Cypher/ZASP in Dilated Cardiomyopathy and Left Ventricular Non-Compaction. Circulation, 2003; 108 (17): 384 Suppl. OCT 28.
- CR Shirley, M Zhao, B Mohapatra, RR Behringer, ML Meistrich. Processing of protamine 2 precursor blocked in mice lacking TP1 and TP2
Biology of Reproduction, 2001;64, 193-194
- CR Shirley, YE Yu, M Zhao, B Mohapatra, RR Behringer, ML Meistrich. Absence of TP1 or TP2 reduces fertility in mice.. Biology of Reproduction, 2000; 62, 110-110
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