The focus of Dr. Manjula Vinayak and her team is to understand the role of antioxidants in regulation of cancer growth with particular reference to Dalton�s lymphoma, and to analyze the molecular mechanism involved in their cancer preventive role. Various antioxidants like a-tocopherol (Vit E), ellagic acid, curcumin, quercetin as well as medicinal plants like Semecarpus anacardium, Terminalia arjuna, Andographis paniculata have been shown to have lymphoma preventive role in mice. These antioxidants enhance antioxidant enzyme activities, down regulate pro-inflammatory cytokines, inhibit cell proliferation & survival, improve apoptosis as well as regress angiogenesis. Various signaling pathways are involved in their anti carcinogenic action like PKC mediated pathway, PI3K pathway via modulation of proinflammatory cytokines, caspases, proto oncogenes, tumor suppressor genes etc.
Currently the second focus of research is to analyze the role of antioxidants in regulation of inflammatory hyperalgesia (pain). Poorly understood initiation process of peripheral and central hyperalgesia is being analyzed at molecular level and the process is targeted by antioxidants like rasveratrol, curcumin to suppress hyperalgesia.

• Supervised 8 Research Scholars who received Ph.D. Degree)
• Number of students presently working for Ph. Degree: 2
• Chaired and delivered Invited lectures in National & International Conferences
• Life member of Society of Biological Chemists (India), Indian Society of Cell Biology, Association of Gerontology (India), Society for Free Radical Research (India), Indian Association of Cancer Biology
• Reviewed several papers for publication in reputed International Journals
• Reviewed several projects for funding by Indian Funding Agencies
• Teaching undergraduates and postgraduates since 1980.
• Refereed of a number of research articles for publication in reputed International Journals
• Evaluated a number of Major Research Projects for financial assistance from Indian Funding Agencies
• Examined Ph.D. thesis
• Delivered lectures in India and abroad

List of 10 major Publications:

1. Pathak C, Jaiswal YK and Vinayak M (2005) Hypomodification of transfer RNA in cancer with respect to queuosine, RNA Biol. 2: 143-148. IF 4.974
2. Pathak C, Jaiswal YK and Vinayak M (2007) Possible involvement of queuine in regulation of cell proliferation. Bio Factors 29:159-173. IF 4.592
3. Dubey R, Singh P, Singh AK, Yadav M, Swati D, Vinayak M, Puerta C, Valerga P, Kumar KR, Sridhar B, and Tewari AK (2014) Polymorphic Signature of the Anti-inflammatory Activity of 2,2{[1,2Phenylenebis(methylene)] bis(sulfanediyl)} bis(4,6dimethylnicotinonitrile. Cryst. Growth Des., In Press DOI: 10.1021/cg401842y IF 4.891
4. Varma G, Rawat P, Jalan M, Vinayak M, Srivastava M (2015) Influence of a CTCF dependent insulator on multiple aspects of enhancer mediated chromatin organization. Mol Cell Biol. IF 4.77
5. Maurya AK and Vinayak M (2015) Abstract A07: Decline in the growth of murine T-cell lymphoma via modulation of PI3K signaling pathway: Key role of quercetin and PI-103. Molecular Cancer Therapeutics 07/2015; 14 (7 Suppl):A07. DOI:10.1158/1538-8514.PI3K14-A07 IF 6.11
6. Vinayak M and Pathak C (2010) Queuosine modification of tRNA: Its divergent role in cellular machinery. Bioscience Reports, 30: 135-148. IF 2.637 (Review article)
7. Das L and Vinayak M (2015) Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer PLoS One (Accepted) IF 3.234
8. Maurya AK and Vinayak M (2015) Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention. Tumor Biology, DOI 10.1007/s13277-015-3634-5 IF 3.61
9. Singh AK and Vinayak M (2015) Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-a, IL-1b and IL-6 Neurochem Res 40(3):463-72 IF:2.59
10. Das L and Vinayak M (2014) Long term effect of curcumin in regulation of glycolytic pathway and angiogenesis via modulation of stress activated genes in prevention of cancer PLoS One DOI: 10.1371/journal.pone.0099583 IF 3.234

Full list of Publications:

1. S. K. Srivastava, R.Das, Manjula Vinayak, R.N.S.Yadav and M.S. Kanungo (1977) Comparative Studies on Myosine ATPase of Skeletal Muscle of Mammals of Different Habitations, Indian J. Biochem. Biophys.,14:241-244.IF 0.574
2. Manjula Vinayak and R.M. Sundari (1980) Age related Qualitative Change in tRNA Population of Rat Skeletal Muscle, J. Biosci., 2:243-253 IF 1.956
3. Manjula Vinayak and R.M. Sundari (1981) Variation in Transfer Ribonucleic Acid Population in Liver of Young, Adult and Old Albino Rats, Indian J. Biochem. Biophys., 18:192-197. IF 0.574
4. Manjula Vinayak and R.M. Sundari (1983) An Improved Method for Extraction and Purification of Total tRNA from Liver and Skeletal Muscle of Rats, Indian J. Zootomy, 24:109-114.
5. Manjula Vinayak and R.M. Sundari (1986) Relative Aminoacylation of tRNA from Skeletal Muscle of Young, Adult and Old Rats, Comp. Physiol. Ecol., 11:131-134.
6. Manjula Vinayak (1986) Aminoacylation of Rat Liver tRNA with Homologous and Heterologous Enzyme Systems during Aging, Biochem. International, 12:479-484.
7. Manjula Vinayak (1987) A Comparison of tRNA Population of Rat Liver and Skeletal Muscle During Aging, Biochem. International, 15:279-285.
8. Manjula Vinayak (1987) Role of tRNA during Aging-A Multifactorial Discussion, pp 1-11.
9. Malancha Sarkar, P.R. Subbarayan and Manjula Vinayak (1994) Transfer RNA Analysis During the Reproductive Cycle of Freshwater Teleost H.fossilis, Mol. Biol. Reports, 20:9-13. IF 2.929
10. P.R. Subbarayan and Manjula Vinayak (1994) Improvement in the Quality of Milt of Heteropneustes fossilis, a Freshwater Teleost, with HCG and its Short Term Preservation, J. Scientific Res., 44:23-26.
11. P.R. Subbarayan and Manjula Vinayak (1995) Analysis of Transfer RNA During the Early Embryogenesis of the Freshwater Teleost, Heteropneustes fossilis, Mol. Biol. Reports, 21:113-118. IF 2.929
12. P.R. Subbarayan and Manjula Vinayak (1996) Normal Embryonic Development of a Freshwater Teleost, Heteropneustes fossilis, J. Scientific Res., 46:23-35.
13. Malancha Sarkar and Manjula Vinayak (1998) Comparison of tRNA Conformation During Different Phase of Reproduction, Mol. Biol. Reports, 25:127-133. IF 2.929
14. Manjula Vinayak and P.R. Subbarayan (1998) Onset of Embryonic Transcription and Translation and Its Important During Embryogenesis of Heteropneustes fossilis, J. Scientific Res. 48:159-170.
15. Manjula Vinayak and Malancha Sarkar (1999) Comparison of tRNA Activity Under Homologous and Heterologous Conditions During the Reproductive Cycle of Heteropneustes fossilis, Mol. Bio. Reports, 26:217-222. IF 2.929
16. Pathak C and Vinayak Manjula (2005) Modulation of Lactate Dehydrogenase Isozymes by modified base Queuine, Mol. Bio. Reports, 32:191-196. IF 2.929
17. Chandramani Pathak, Yogesh K. Jaiswal and Manjula Vinayak (2005) Hypomodification of transfer RNA in cancer with respect to queuosine, RNA Biol. 2: 143-148. IF 5.559
18. Chandramani Pathak, Yogesh. K. Jaiswal and Manjula Vinayak (2007) Possible involvement of queuine in regulation of cell proliferation. Bio Factors 29:159-173. IF 4.933
19. Nibha Verma and Manjula Vinayak (2008) Antioxidant action of Andographis paniculata on Lymphoma. Mol. Biol. Reports, 35: 535-540. IF 2.929
20. Chandramani Pathak, Yogesh. K. Jaiswal and Manjula Vinayak (2008) Modulation in the activity of Lactate Dehydrogenase and level of c-Myc and c-Fos by modified base queuine in cancer. Cancer Biology and Therapy, 7: 85-91. IF 2.711 Erratum: Cancer Biology and Therapy, (2008) 7: 1315-1315.
21. Chandramani Pathak, Yogesh. K. Jaiswal and Manjula Vinayak (2008) Modified base queuine promotes cellular antioxidant defense system in cancer. Bioscience Reports, 28: 73-81. IF 3.061
22. Chandramani Pathak, Yogesh. K. Jaiswal and Manjula Vinayak (2008) Queuine mediated inhibition in phosphorylation of tyrosine phosphoproteins in cancer. Mol. Biol. Reports, 35: 369-374. IF IF 2.929
23. Nibha Verma and Manjula Vinayak (2009) Semecarpus anacardium Promotes Antioxidant Defense System and Inhibits Anaerobic Metabolism during Development of Lymphoma. Bioscience Reports, 29: 151-164. IF 3.061
24. Nibha Verma and Manjula Vinayak (2009) Effect of Terminalia arjuna on Antioxidant Defense System in Cancer. Mol. Biol. Reports, 36(1): 159-164. IF 2.929
25. Manjula Vinayak and Chandramani Pathak (2010) Queuosine modification of tRNA: Its divergent role in cellular machinery. Bioscience Reports, 30: 135-148. IF 3.061 (Review article)
26. Sharma R and Manjula Vinayak (2011) Tocopherol attenuates NF-kB activation and proinflammatory cytokine IL-6 secretion in cancer bearing mice. Bioscience Reports, 31: 421-428. IF 3.061
27. Mishra S and Manjula Vinayak (2011) Anti-carcinogenic action of ellagic acid mediated via modulation of oxidative stress regulated genes in Dalton lymphoma bearing mice. Leukemia & Lymphoma, 52(11):2155-61 IF 2.580
28. Das L and Manjula Vinayak (2012) Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-kB signaling in lymphoma bearing mice. Bioscience Reports, 32:161�170. IF 3.061
29. Sharma R and Manjula Vinayak (2012) Antioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolism. Leukemia & Lymphoma, 53: 1203-1210. IF 2.580
30. Verma N and Manjula Vinayak (2012) Low Dose of Doxorubicin Improves Antioxidant Defence System and Modulates Anaerobic Metabolism during Development of Lymphoma. Ind. J. Pharmacol., 44:308-313. IF 0.303
31. Mishra S and Vinayak M (2013) Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway. Mol. Biol. Reports, 40:1417-28 IF 2.024
32. Sharma R and Vinayak M (2013) a- Tocopherol prevent lymphoma by improving antioxidant defence system of mice. Mol. Biol. Reports, 40:839-49 IF 2.024
33. Das L and Vinayak M (2014) Long term effect of curcumin in regulation of glycolytic pathway and angiogenesis via modulation of stress activated genes in prevention of cancer PLoS One DOI: 10.1371/journal.pone.0099583 IF 3.234
34. Das L and Vinayak M (2014) Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1a and IL-1�) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice, International Immunopharmacology,20:141-147 IF 2.472
35. Dubey R, Singh P, Singh AK, Yadav M, Swati D, Vinayak M, Puerta C, Valerga P, Kumar KR, Sridhar B, and Tewari AK (2014) Polymorphic Signature of the Anti-inflammatory Activity of 2,2{[1,2Phenylenebis(methylene)] bis(sulfanediyl)} bis(4,6dimethylnicotinonitrile. Cryst. Growth Des., 14: 1347-1356 IF 4.891
36. Mishra S and Vinayak M (2014) Ellagic acid inhibits PKC signaling by improving antioxidant defense system in Murine T cell lymphoma. Molecular Biology Reports, 41(7):4187-97. IF 2.024
37. Das L and Vinayak M (2014) Long term effect of curcumin down regulates expression of TNF-a and IL-6 via modulation of ETS and NF-?B transcription factor in liver of lymphoma bearing mice. Leukemia & Lymphoma, 55(11):2627-36. IF 2.891
38. Mishra S and Vinayak M (2014) Ellagic acid induces novel and atypical PKC isoforms and promotes caspase-3 dependent apoptosis by blocking energy metabolism. Nutrition and Cancer: An International Journal, 66(4):675-81 IF 2.322
39. Maurya AK and Vinayak M (2015) Anticarcinogenic action of quercetin by downregulation of Phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Molecular Biology Report. 42(9):1419-29 IF 2.02
40. Mishra S, Vinayak M (2015) Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice. BMC Complement Altern Med. 15:281- 288 IF 2.02
41. Varma G, Rawat P, Jalan M, Vinayak M, Srivastava M (2015) Influence of a CTCF dependent insulator on multiple aspects of enhancer mediated chromatin organization. Mol Cell Biol. IF 4.77
42. Maurya AK and Vinayak M (2015) Abstract A07: Decline in the growth of murine T-cell lymphoma via modulation of PI3K signaling pathway: Key role of quercetin and PI-103. Molecular Cancer Therapeutics 07/2015; 14 (7 Suppl):A07. DOI:10.1158/1538-8514.PI3K14-A07 IF 6.11
43. Maurya AK and Vinayak M (2015) Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention. Tumor Biology, DOI 10.1007/s13277-015-3634-5 IF 3.61
44. Das L and Vinayak M (2015) Long Term Effect of Curcumin in Restoration of Tumour Suppressor p53 and Phase-II Antioxidant Enzymes via Activation of Nrf2 Signalling and Modulation of Inflammation in Prevention of Cancer, PLoS One, In Press doi: 10.1371/journal.pone.0124000. IF 3.234
45. Singh AK and Vinayak M (2015) Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-a, IL-1b and IL-6 Neurochem Res 40(3):463-72 IF:2.59
46. Maurya AK and Vinayak M (2015) Quercetin regresses Dalton�s lymphoma growth via suppression of PI3K/AKT signaling leading to up regulation of p53 and decrease in energy metabolism. Nutrition and Cancer: An International Journal, 67(2):354-63 IF 2.322