| Sukala Prasad |
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Professor
Ph D (BHU)
Contact Information:
(O)091-542-6702517 (O), 2575842 (R), 09415812467(M) (R), (M), FAX:091-542-2368174
Email Id:[email protected]
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| Academic Qualifications: |
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S. No. | Degree | Institution | Year |
| 1. | B.Sc. | Banaras Hindu University, Varanasi | 1978 |
| 2. | M.Sc. | Banaras Hindu University, Varanasi | 1980 |
| 3. | Ph. D. | Banaras Hindu University, Varanasi | 1988 | | | |
| Brief writeup on area of specialization/awards/achievements: |
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Area of specialization:
Currently work is going on the molecular mechanisms of aging and effects of age and age- associated diseases on learning, memory and cognition. Following are the major projects going on using mouse model:
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Expression of fragile X mental retardation (Fmr1) gene and its encoded mRNA binding protein called Fragile X mental retardation protein (FMRP) as a function of age.
- Age and sex dependent differential interaction of transcription factors with upstream promoter sequences of Fmr1 gene
- Differential methylation of CpG island in upstream sequences
- Modulation of Fmr1 gene expression by sex steroid hormones and altering the activity of glutamate receptors.
- Role of Fmr1 gene in learning and memory using amnesic mouse model.
- Molecular mechanisms, behavioral and electrophysiological analysis of synaptic plasticity.
- Molecular mechanism of diabetes mellitus (DM) and Parkinson�s disease (PD) altered learning, memory and cognition.
- Role of herbal drugs/preparations in the amelioration of DM and PD induced decline in learning and memory.
Achievements:
Membership of Scientific Bodies
1. Life member of Association of Gerontology (India)
2. Life member of Society of Biological Chemists, India
3. Life member of Indian Society of Cell Biology, India
4. Life member of Indian Academy Neurosciences
5. Member of National Academy of Sciences, India, Allahabad (NASI)
Award:
1. Lennox-Boyd Trust Award, Medical Research Council (MRC), UK.
2. AMBO International Fellowship, Osaka, Japan,
3. Treasurer, Association of Gerontology (India)
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| A. Projects Undertaken as PI: |
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| S. No. | Name of the Project | Duration | Source of Funding | Amount of Funding (Rs)
| | 1. | Regulation of Fmr-1 gene expression by sex steroid hormones in the brain of aging mouse | 2010-13 | BRNS (DAE), Mumbai | ------
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| Any additional information: |
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List of major Publications:
- Prasad S and Pandey RS (2010) Aging: The Current Perspectives In Book: Recent Trends in Biotechnology Volume 2 (Eds. Sharma B et al, Nova Publishers Inc, New York, U.S.A.) (In Press)
- Singh K and Prasad S (2008) Age-related analysis of methylation of Fmr-1 promoter in mouse brain and modulation by sex steroid hormones. Biogerontology 9 (6): 465-475 (IF-3.545)
- S. Prasad and Kanchan Singh (2008) Interactions of USF1/USF2 and α Pal/Nrf 1 to Fmr-1 promoter increase in mouse brain during aging. Biochem. Biophys. Res. Com. 376 (2): 347-351 (IF-2.755)
- Singh M, Singh S, Prasad S, Gambhir IS (2008) Nanotechnology in medicine and antibacterial effect of silver nanoparticles. The Digest Journal of Nanomaterials and Biostructures, 3 (3): 103-107
- Prasad S and Singh K (2008) Age- and sex-dependent differential interaction of nuclear trans-acting factors with Fmr-1 promoter in mice brain. Neurochem. Res. 233(6), 1028-1035 (IF-2.139)
- Singh K and Prasad S (2007) Differential expression of Fmr-1 mRNA and FMRP in female mice brain during aging. Mol. Biol. Rep. (Published on line) (IF-1.75)
- Singh K, Gaur P and Prasad S (2007) (Online pub 29 Nov. 2006) Fragile x mental retardation (Fmr-1) gene expression is down regulated in brain of mice during aging. Mol. Biol. Rep. 34:173-181 (IF-1.75)
- Singh S, Prasad S and Gambhir IS (2007) Review: Biomarkers in the diagnosis of dementia of Alzheimer�s type. Ind. J. Ger. Ment. Health, 3: 18-30.
9. Thakur MK and Prasad S (2005) Book: Molecular and Cellular Neurobiology Eds. MK Thakur and S Prasad, Published by Narosa Publishing House Pvt. Ltd., New Delhi
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